Department of Epidemiology, University of Milan, Milan, Italy.
Curr Opin Clin Nutr Metab Care. 2012 Jul;15(4):368-73. doi: 10.1097/MCO.0b013e3283539f81.
There is a growing body of in-vivo evidences that sucrose-rich diets cause mutations in the rat colon epithelium, with several biological mechanism hypothesized, but epidemiological studies have yielded conflicting results. In order to provide a quantification of the magnitude of the risk of colon cancer for high intake of added sugar, high dietary glycemic index and glycemic load, we performed a meta-analysis based on a systematic review of the literature to date.
Recent epidemiological data indicate a lack of association between high intake of added sugar, high-glycemic index and glycemic load diets and risk of colon cancer.
There is no consistent evidence from epidemiological studies, although a modest excess risk emerged in case-control studies, that added sugars, dietary glycemic index and glycemic load are associated with increased risk of colon cancer, independently from their effect on energy intake, overweight, obesity and diabetes, which are related to excess colon cancer risk.
越来越多的体内证据表明，富含蔗糖的饮食会导致大鼠结肠上皮突变，有几种生物学机制被假设，但流行病学研究得出了相互矛盾的结果。为了定量评估高糖摄入、高膳食血糖指数和血糖负荷对结肠癌风险的影响，我们对迄今为止的文献进行了系统综述和荟萃分析。
最近的流行病学数据表明，高糖摄入、高血糖指数和高血糖负荷饮食与结肠癌风险之间没有关联。
尽管病例对照研究显示出适度的超额风险，但来自流行病学研究的一致证据表明，添加糖、膳食血糖指数和血糖负荷与结肠癌风险增加有关，这与它们对能量摄入、超重、肥胖和糖尿病的影响无关，这些因素与结肠癌风险增加有关。
