Department of Chemistry, University of Washington, Seattle, Washington 98195, USA.
J Am Chem Soc. 2012 May 2;134(17):7309-12. doi: 10.1021/ja3022973. Epub 2012 Apr 23.
This communication describes a new class of semiconducting polymer nanoparticle-quantum dot hybrid with high brightness, narrow emission, near-IR fluorescence, and excellent cellular targeting capability. Using this approach, we circumvented the current difficulty with obtaining narrow-band-emitting and near-IR-fluorescing semiconducting polymer nanoparticles while combining the advantages of both semiconducting polymer nanoparticles and quantum dots. We further demonstrated the use of this new class of hybrid nanomaterial for effective and specific cellular and subcellular labeling without any noticeable nonspecific binding. This hybrid nanomaterial is anticipated to find use in a variety of in vitro and in vivo biological applications.
本通讯描述了一类新型的半导体聚合物纳米粒子-量子点杂化材料，具有高亮度、窄发射、近红外荧光和优异的细胞靶向能力。通过这种方法，我们避免了目前获得窄带发射和近红外荧光半导体聚合物纳米粒子的困难，同时结合了半导体聚合物纳米粒子和量子点的优点。我们进一步证明了这种新型杂化纳米材料可用于有效和特异性的细胞和亚细胞标记，而没有任何明显的非特异性结合。这种杂化纳米材料预计将在各种体外和体内生物应用中得到应用。
