Enteric Virus Group, Murdoch Childrens Research Institute, Royal Children's Hospital, Flemington Road, Parkville, Melbourne, VIC 3052, Australia.
Vaccine. 2012 Apr 27;30 Suppl 1:A152-8. doi: 10.1016/j.vaccine.2011.07.119.
A large rotavirus gastroenteritis outbreak occurred in the Alice Springs region of the Northern Territory, Australia from the 12th of March until the 11th of July 2007. The outbreak occurred five months after the introduction of the Rotarix™ vaccine. Electropherotype and sequence analysis demonstrated that a single G9P[8] strain was responsible for the outbreak and that the strain remained highly conserved during the outbreak period. The outbreak strain contained amino acid changes in regions of the VP7 and NSP4 genes, with known biological function, when compared to previously characterised G9P[8] strains from Australia and other international locations. The recent vaccine introduction was unlikely to have influenced genotype selection in this setting. Importantly, Rotarix™ vaccine was highly effective against the G9P[8] outbreak strain.
2007 年 3 月 12 日至 7 月 11 日，澳大利亚北领地爱丽丝泉地区发生了一起大型轮状病毒肠胃炎暴发疫情。该疫情发生在 Rotarix™疫苗引入五个月后。电泳图谱和序列分析表明，单一的 G9P[8] 血清型菌株是此次暴发的罪魁祸首，并且在暴发期间该菌株保持高度保守。与来自澳大利亚和其他国际地区的先前表征的 G9P[8] 菌株相比，暴发菌株在 VP7 和 NSP4 基因的具有已知生物学功能的区域含有氨基酸变化。最近的疫苗接种不太可能影响这种情况下的基因型选择。重要的是，Rotarix™疫苗对 G9P[8] 暴发株具有高度的有效性。
