Klebanoff S J
Infect Immun. 1979 Jul;25(1):153-6. doi: 10.1128/iai.25.1.153-156.1979.
Estradiol 17 beta prevented the fall in the microbicidal activity of the myeloperoxidase-H2O2-halide system induced by high H2O2 concentrations. In contrast, when the H2O2 (and halide) concentrations were low the myeloperoxidase-H2O2-halide antimicrobial system was inhibited by estradiol. These properties of estradiol 17 beta were shared by estradiol 17 alpha, estrone, estriol, ethinyl estradiol, and phenol, but not by estradiol-3-benzoate, testosterone, progesterone, hydroxyprogesterone, cortisone, hydrocortisone, or deoxycorticosterone.
17β-雌二醇可防止高浓度过氧化氢诱导的髓过氧化物酶-H2O2-卤化物系统杀菌活性下降。相反,当H2O2(和卤化物)浓度较低时,17β-雌二醇会抑制髓过氧化物酶-H2O2-卤化物抗菌系统。17α-雌二醇、雌酮、雌三醇、炔雌醇和苯酚也具有17β-雌二醇的这些特性,但17β-雌二醇苯甲酸酯、睾酮、孕酮、羟孕酮、可的松、氢化可的松或脱氧皮质酮则没有。