Kita E, Takahashi S, Yasui K, Kashiba S
Infect Immun. 1985 Jul;49(1):238-43. doi: 10.1128/iai.49.1.238-243.1985.
Studies of the effect of sex hormones on the susceptibility of mice to the disseminated gonococcal infection demonstrated significantly enhanced susceptibility of mice injected with estrogen (17 beta-estradiol). In mice treated with estradiol, bacteremia progressively developed within 12 h postinoculation and mice died within the next 6 h, whereas bacteremia in mice treated with progesterone was completely cleared within 3 h postinoculation. The administration of estradiol affected the function of polymorphonuclear leukocytes (PMN) responsible for eliminating gonococci, but the administration of progesterone did not. The bactericidal activity of PMN mediated by myeloperoxidase was affected by estradiol, but the capacity of PMN to release superoxide anion was not. Furthermore, peritoneal cell analysis demonstrated that the infiltration of PMN in the peritoneal cavity of estradiol-treated mice significantly decreased when mice were injected intraperitoneally with gonococci. These effects on PMN by estradiol may play an important role in the enhanced susceptibility of estradiol-treated mice to gonococcal infection.
关于性激素对小鼠播散性淋球菌感染易感性影响的研究表明，注射雌激素（17β-雌二醇）的小鼠易感性显著增强。在用雌二醇处理的小鼠中，接种后12小时内逐渐发生菌血症，随后6小时内小鼠死亡，而用孕酮处理的小鼠菌血症在接种后3小时内完全清除。雌激素的给药影响了负责清除淋球菌的多形核白细胞（PMN）的功能，但孕酮的给药则没有。髓过氧化物酶介导的PMN杀菌活性受雌激素影响，但PMN释放超氧阴离子的能力不受影响。此外，腹膜细胞分析表明，当向小鼠腹腔内注射淋球菌时，雌激素处理的小鼠腹腔内PMN的浸润显著减少。雌激素对PMN的这些影响可能在雌激素处理的小鼠对淋球菌感染易感性增强中起重要作用。
