过氧化物酶-H2O2-卤化物系统的杀支原体活性。
Mycoplasmacidal activity of peroxidase-H2O2-halide systems.
作者信息
Jacobs A A, Low I E, Paul B B, Strauss R R, Sbarra A J
出版信息
Infect Immun. 1972 Jan;5(1):127-31. doi: 10.1128/iai.5.1.127-131.1972.
Abstract
A mycoplasmacidal system consisting of myeloperoxidase (MPO)-containing granules, H(2)O(2), and a halide is described. In all parameters measured, it appears to be identical to the MPO-H(2)O(2)-halide bactericidal system previously reported. It has a pH optimum of approximately 5.5 and an optimal MPO:H(2)O(2) ratio of 1:25. The halide requirement can be satisfied by either chloride or iodide. Through the use of taurine or horseradish peroxidase substitution, chloride-mediated killing can be distinguished from iodide-mediated killing. The relationship of this mycoplasmacidal system to other mycoplasmacidal systems and to host surveillance of mycoplasma is discussed.
摘要
描述了一种由含髓过氧化物酶（MPO）的颗粒、H₂O₂和卤化物组成的杀支原体系统。在所有测量参数中，它似乎与先前报道的MPO - H₂O₂ - 卤化物杀菌系统相同。其最适pH约为5.5，MPO:H₂O₂的最佳比例为1:25。卤化物需求可由氯化物或碘化物满足。通过使用牛磺酸或辣根过氧化物酶替代物，可以区分氯化物介导的杀伤和碘化物介导的杀伤。讨论了该杀支原体系统与其他杀支原体系统以及支原体宿主监测的关系。
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