一种用于组织切片中体外形成的淀粉样原纤维和蛋白质聚集体光学成像的五聚体发光共轭低聚噻吩。
A pentameric luminescent-conjugated oligothiophene for optical imaging of in vitro-formed amyloid fibrils and protein aggregates in tissue sections.
作者信息
Nilsson K Peter R, Lindgren Mikael, Hammarström Per
机构信息
Department of Chemistry, IFM, Linköping University, Linköping, Sweden.
出版信息
Methods Mol Biol. 2012;849:425-34. doi: 10.1007/978-1-61779-551-0_29.
PMID:22528107
Abstract
Luminescent-conjugated oligo- and polythiophenes (LCOs and LCPs) are valuable tools for optical imaging of a plethora of protein aggregates associated with amyloidoses. Here, we describe the utilization of an anionic pentameric LCO, p-FTAA, for staining of protein aggregates in a variety of platforms, including in vitro-formed amyloid fibrils and tissue sections.
摘要
发光共轭寡聚和聚噻吩（LCOs和LCPs）是用于对与淀粉样变性相关的大量蛋白质聚集体进行光学成像的宝贵工具。在此，我们描述了一种阴离子五聚体LCO，即p-FTAA，在多种平台上对蛋白质聚集体进行染色的应用，包括体外形成的淀粉样纤维和组织切片。
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