Nilsson K Peter R, Lindgren Mikael, Hammarström Per
Department of Chemistry, IFM, Linköping University, Linköping, Sweden.
Methods Mol Biol. 2012;849:425-34. doi: 10.1007/978-1-61779-551-0_29.
Luminescent-conjugated oligo- and polythiophenes (LCOs and LCPs) are valuable tools for optical imaging of a plethora of protein aggregates associated with amyloidoses. Here, we describe the utilization of an anionic pentameric LCO, p-FTAA, for staining of protein aggregates in a variety of platforms, including in vitro-formed amyloid fibrils and tissue sections.
发光共轭寡聚和聚噻吩（LCOs和LCPs）是用于对与淀粉样变性相关的大量蛋白质聚集体进行光学成像的宝贵工具。在此，我们描述了一种阴离子五聚体LCO，即p-FTAA，在多种平台上对蛋白质聚集体进行染色的应用，包括体外形成的淀粉样纤维和组织切片。
