Department of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajiicho Kawaramachi Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan.
Jpn J Radiol. 2012 Jul;30(6):486-91. doi: 10.1007/s11604-012-0073-8. Epub 2012 Apr 21.
To evaluate the effect of patient factors on radiation dermatitis for patients with breast cancer who underwent postoperative radiotherapy after breast-conserving surgery.
The study population comprised 87 patients who underwent breast-conserving surgery followed by 50 Gy/25 fractions (median) of radiotherapy with or without boost radiation (10 Gy/5 fractions). We examined their treated and contralateral breast skin color by use of an objective analyzer, and expressed findings as L, a, b ratios by dividing by pre-RT values. Next, we examined correlation between patient factors (age, height, body weight, and body mass index, BMI) and change of L and a values by use of correlation coefficients.
Radiation therapy caused changes in a and L ratios (p < 0.0001) but not in b ratio. The a ratio (reddish) increased 1.4-fold and peaked after radiotherapy. The L ratio (darkening) decreased by 10 % and reached a minimum value between completion of radiotherapy and 1 month after treatment. Although, age and height did not affect Δ value, body weight and BMI correlated significantly with Δa value (p = 0.0012 and 0.0017) not with ΔL value.
Body weight and BMI predict degree of radiation dermatitis, and more reddish dermatitis was observed for heavier patients than for their lighter counterparts.
评估患者因素对保乳手术后接受术后放疗的乳腺癌患者放射性皮炎的影响。
研究对象为 87 例接受保乳手术并接受 50Gy/25 次分割（中位数）放疗（有或无追加放疗 10Gy/5 次）的患者。我们使用客观分析仪检查其治疗侧和对侧乳房皮肤颜色，并通过将治疗前的数值除以治疗后的数值，将结果表示为 L、a、b 比值。然后，我们通过相关系数检查患者因素（年龄、身高、体重和体重指数 BMI）与 L 值和 a 值变化之间的相关性。
放疗导致 a 和 L 比值发生变化（p<0.0001），但 b 比值没有变化。a 比值（变红）增加了 1.4 倍，在放疗后达到峰值。L 比值（变暗）下降了 10%，在放疗完成后和治疗后 1 个月达到最低值。虽然年龄和身高不影响Δ值，但体重和 BMI 与Δa 值显著相关（p=0.0012 和 0.0017），与ΔL 值无关。
体重和 BMI 预测放射性皮炎的程度，体重较重的患者比体重较轻的患者出现更明显的红斑性皮炎。
