Institute of Cell Signalling, University of Nottingham, Nottingham, UK.
Purinergic Signal. 2012 Sep;8(3):587-98. doi: 10.1007/s11302-012-9311-x. Epub 2012 Apr 15.
The directional movement of cells can be regulated by ATP, certain other nucleotides (e.g., ADP, UTP), and adenosine. Such regulation occurs for cells that are "professional phagocytes" (e.g., neutrophils, macrophages, certain lymphocytes, and microglia) and that undergo directional migration and subsequent phagocytosis. Numerous other cell types (e.g., fibroblasts, endothelial cells, neurons, and keratinocytes) also change motility and migration in response to ATP, other nucleotides, and adenosine. In this article, we review how nucleotides and adenosine modulate chemotaxis and motility and highlight the importance of nucleotide- and adenosine-regulated cell migration in several cell types: neutrophils, microglia, endothelial cells, and cancer cells. We also discuss difficulties in conducting experiments and drawing conclusions regarding the ability of nucleotides and adenosine to modulate the migration of professional and non-professional phagocytes.
细胞的定向运动可以被 ATP、某些其他核苷酸（如 ADP、UTP）和腺苷调节。这种调节发生在“专业吞噬细胞”（如中性粒细胞、巨噬细胞、某些淋巴细胞和小胶质细胞）中，它们会发生定向迁移和随后的吞噬作用。许多其他细胞类型（如成纤维细胞、内皮细胞、神经元和角质细胞）也会响应 ATP、其他核苷酸和腺苷改变其运动性和迁移性。在本文中，我们回顾了核苷酸和腺苷如何调节趋化性和运动性，并强调了核苷酸和腺苷调节几种细胞类型（如中性粒细胞、小胶质细胞、内皮细胞和癌细胞）中细胞迁移的重要性。我们还讨论了在进行实验和得出关于核苷酸和腺苷调节专业和非专业吞噬细胞迁移能力的结论方面存在的困难。
