John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia.
Nat Immunol. 2010 Aug;11(8):681-8. doi: 10.1038/ni.1900. Epub 2010 Jul 20.
This paper synthesizes recent progress toward understanding the integrated control systems and fail-safes that guide the quality and quantity of antibody produced by B cells. We focus on four key decisions: (1) the choice between proliferation or death in perifollicular B cells in the first 3 days after antigen encounter; (2) differentiation of proliferating perifollicular B cells into extrafollicular plasma cells or germinal center B cells; (3) positive selection of B cell antigen receptor (BCR) affinity for foreign antigen versus negative selection of BCR affinity for self antigen in germinal center B cells; and (4) survival versus death of antibody-secreting plasma cells. Understanding the engineering of these control systems represents a challenging future step for treating disorders of antibody production in autoimmunity, allergy and immunodeficiency.
本文综合了近期在理解 B 细胞产生抗体的质量和数量的综合控制系统和故障保护方面的进展。我们重点关注四个关键决策：（1）在抗原接触后前 3 天滤泡周围 B 细胞中增殖或死亡的选择；（2）增殖滤泡周围 B 细胞分化为滤泡外浆细胞或生发中心 B 细胞；（3）生发中心 B 细胞中 B 细胞抗原受体（BCR）对外来抗原的亲和力的阳性选择与 BCR 对自身抗原的亲和力的阴性选择；（4）分泌抗体的浆细胞的存活或死亡。理解这些控制系统的工程设计代表了治疗自身免疫、过敏和免疫缺陷中抗体产生障碍的具有挑战性的未来步骤。
