Department of Clinical Pharmacology and Therapeutics, Nizam's Institute of Medical Sciences, Hyderabad, India.
Indian J Pharmacol. 2012 Mar;44(2):230-3. doi: 10.4103/0253-7613.93855.
The aim of the present study was to validate and compare novel methods to determine aortic blood pressure non-invasively based on Oscillometric Pulse Wave Velocity (PWV) measurement using four limb-cuff pressure waveforms and two lead Electrocardiogram (ECG) with a validated tonometric pulse wave analysis system in patients.
After receiving the consent, in 49 patients with hypertension, coronary artery disease, diabetes mellitus, PWV, and central blood pressures were recorded in a randomised manner using both the oscillometric and tonometric devices. All recordings were performed 10 minutes after the patient lying comfortably in a noise-free temperature-controlled room. The test was performed between 09 am and 10 am after overnight fast. A minimum of three measurements were performed by the same skilled and trained operator. From the raw data obtained with two devices, software calculated the final vascular parameters.
A total of 49 patients (8 women and 41 men), of mean age 40.5 years (range: 19-81 years) participated in the present study. After transforming the brachial pressures into aortic pressures, the correlation coefficient between the Aortic Systolic Pressure (ASP) values obtained with two methods was 0.9796 (P<0.0001). The mean difference between ASP with two methods was 0.3 mm Hg. Similarly, Aortic Diastolic Pressure (ADP) values obtained with two methods also correlated significantly with correlation coefficient of 0.9769 (P<0.0001). The mean difference of ADP was 0.2 mm Hg. In case of Aortic Pulse Pressure (APP), the mean difference was 0.1 mm Hg. All parameters of central aortic pressures obtained with two methods correlated significantly.
The new method of transforming the Carotid Femoral PWV (cfPWV) and brachial blood pressure values into aortic blood pressure values seems to be reasonably good. The significant correlation between the values obtained by tonometric device and oscillometric PWV method shows that the latter can be used non-invasively in patients to find the aortic pressure.
本研究的目的是验证并比较使用四肢袖带压力波形和两种导联心电图（ECG）基于示波脉搏波速度（PWV）测量的新型无创方法，以确定主动脉血压，该方法与经验证的示波脉搏波分析系统在患者中进行比较。
在 49 名高血压、冠心病、糖尿病患者中，征得同意后，以随机方式使用示波和示波设备记录 PWV 和中心血压。所有记录均在患者舒适地躺在安静、温度可控的房间 10 分钟后进行。测试在禁食过夜后上午 09 点至 10 点之间进行。由同一位熟练且经过培训的操作员进行至少三次测量。从两种设备获得的原始数据中，软件计算出最终的血管参数。
共有 49 名患者（8 名女性和 41 名男性），平均年龄 40.5 岁（范围：19-81 岁）参与了本研究。将肱动脉压力转换为主动脉压力后，两种方法获得的主动脉收缩压（ASP）值之间的相关系数为 0.9796（P<0.0001）。两种方法之间 ASP 的平均差值为 0.3mmHg。同样，两种方法获得的主动脉舒张压（ADP）值也有显著相关性，相关系数为 0.9769（P<0.0001）。ADP 的平均差值为 0.2mmHg。在主动脉脉搏压（APP）方面，平均差值为 0.1mmHg。两种方法获得的所有中心主动脉压力参数均有显著相关性。
将颈股脉搏波速度（cfPWV）和臂部血压值转换为主动脉血压值的新方法似乎相当不错。示波设备和示波 PWV 方法获得的数值之间具有显著相关性，表明后者可在患者中无创使用以确定主动脉压力。
