Department of Cardiology, Queen Elizabeth Hospital Birmingham and University of Birmingham, Birmingham, UK.
Heart. 2010 Jun;96(11):817-23. doi: 10.1136/hrt.2009.184879. Epub 2010 Apr 20.
Chronic kidney disease is associated with elevated cardiovascular risk, and heart failure and arrhythmias are the biggest causes of cardiovascular death in this population. Increased arterial stiffness is a hallmark of chronic kidney disease and is associated with adverse alterations in cardiac structure and function that may predispose to an increased risk of cardiovascular death. These changes are already apparent in early kidney disease, which is highly prevalent in the developed world. The mechanisms underlying increased arterial stiffness in chronic kidney disease are undoubtedly complex, but an understanding is paramount to enable the development of novel therapeutic strategies to prevent or reverse this pathophysiology and therefore reduce the cardiovascular disease burden in this high-risk cohort.
慢性肾脏病与心血管风险升高有关，心力衰竭和心律失常是该人群心血管死亡的最大原因。动脉僵硬度增加是慢性肾脏病的一个标志，与心脏结构和功能的不良改变有关，这些改变可能增加心血管死亡的风险。这些变化在早期肾脏病中已经很明显，而早期肾脏病在发达国家非常普遍。慢性肾脏病中动脉僵硬度增加的机制无疑是复杂的，但了解这些机制对于开发新的治疗策略以预防或逆转这种病理生理学，从而降低高危人群的心血管疾病负担至关重要。
