Kadam P R, Balsara B R, Zafaraullah K Z, Dadabhoy K D, Bhisey A N, Advani S H
Department of Medical Oncology, Tata Memorial Hospital, Bombay, India.
Cancer Genet Cytogenet. 1990 Nov 1;50(1):89-96. doi: 10.1016/0165-4608(90)90241-2.
Cytogenetic studies were carried on 11 patients with erythroleukemia (EL). Most of these patients showed major chromosomal abnormalities (MAKA), karyotypic instability, and complex chromosomal rearrangements. On the basis of the cytogenetic criteria, 10 patients could be distinguished into erythroid (9 cases) and myeloid types of EL (1 case). The patients did not show any consistent chromosomal abnormality. However, abnormalities of chromosomes 1, 3, 7, 8, 16, and 17 were seen in more than one patient. In patients with the erythroid type of EL, besides the MAKA pattern, three patients showed increased frequency of hyperdiploid polyploid cells ranging from triploidy to tetraploidy.
对11例红白血病（EL）患者进行了细胞遗传学研究。这些患者大多表现出主要染色体异常（MAKA）、核型不稳定性和复杂的染色体重排。根据细胞遗传学标准，10例患者可分为红系（9例）和髓系EL（1例）。患者未表现出任何一致的染色体异常。然而，在不止一名患者中发现了1、3、7、8、16和17号染色体异常。在红系EL患者中，除MAKA模式外，3例患者显示超二倍体多倍体细胞频率增加，范围从三倍体到四倍体。
