Kocova M J, Sandberg A A
Cancer Genet Cytogenet. 1985 Jun;17(2):143-50. doi: 10.1016/0165-4608(85)90024-x.
A case of erythroleukemia (EL; FAB M6) is presented in which the leukemic cells of the marrow were characterized by two ranges in the chromosome number, i.e., one hypodiploid and another near-tetraploid. All characteristics of major karyotypic abnormalities (MAKA) were present, i.e., increased karyotype instability with variation of the chromosome count from metaphase to metaphase, dicentrics, acentrics, marker chromosomes, double minute chromosomes (DMs), and centromere spreading. All of these events were variably represented from metaphase to metaphase. The prognosis was poor, with survival of 1 month after the diagnosis of EL. The meaning of extreme MAKA in the classification of EL is discussed.
本文报告1例红白血病（EL；FAB M6），其骨髓白血病细胞具有两个染色体数范围的特征，即一个亚二倍体范围和另一个近四倍体范围。存在主要核型异常（MAKA）的所有特征，即核型不稳定性增加，中期到中期染色体计数变化，双着丝粒染色体、无着丝粒染色体、标记染色体、双微体染色体（DMs）和着丝粒扩展。所有这些情况在不同中期表现各异。预后较差，EL诊断后存活1个月。讨论了EL分类中极端MAKA的意义。
