Bernheim A, Berger R, Daniel M T, Valensi F, Flandrin G
Cancer Genet Cytogenet. 1983 Sep;10(1):1-10. doi: 10.1016/0165-4608(83)90099-7.
A cytogenetic and cytological study of 16 cases of erythroleukemia (M6) is reported. No chromosomal abnormalities were observed in 10 cases. Abnormalities were present in the other 6 cases, of which 4 were complex abnormalities. It was not possible to establish any correlation between the occurrence of morphologic abnormalities of the erythroid and megakaryocyte-platelet series and the presence of cytogenetic defects. Studies of mitoses by cytologic and cytogenetic methods concurrently performed in some cases suggest that two types of erythroleukemia can be distinguished: (1) cases with chromosomal abnormalities and a persistence of erythroblast mitoses in vitro (which suggests that the erythroblasts belong to the leukemic clone) and (2) cases with no chromosome abnormality and a disappearance of erythroblast mitoses after culture, suggesting that the erythroblasts are not members of the leukemic clone.
本文报道了16例红白血病（M6）的细胞遗传学和细胞学研究。10例未观察到染色体异常。其他6例存在异常，其中4例为复杂异常。无法在红系和巨核细胞 - 血小板系列的形态学异常发生与细胞遗传学缺陷存在之间建立任何关联。在某些病例中同时采用细胞学和细胞遗传学方法对有丝分裂进行的研究表明，可区分出两种类型的红白血病：（1）伴有染色体异常且体外成红细胞有丝分裂持续存在的病例（这表明成红细胞属于白血病克隆）；（2）无染色体异常且培养后成红细胞有丝分裂消失的病例，提示成红细胞不是白血病克隆的成员。
