Institute of Materials Engineering and Physics, Applied Science and Technology Department, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Turin, Italy.
J Mater Sci Mater Med. 2012 Oct;23(10):2369-80. doi: 10.1007/s10856-012-4643-1. Epub 2012 Apr 25.
In this work, the use of foam-like glass-ceramic scaffolds as trabecular coatings on ceramic prosthetic devices to enhance implant osteointegration is proposed. The feasibility of this innovative device was explored in a simplified, flat geometry: glass-ceramic scaffolds, prepared by polymeric sponge replication and mimicking the trabecular architecture of cancellous bone, were joined to alumina square substrates by a dense glass coating (interlayer). The role played by different formulations of starting glasses was examined, with particular care to the effect on the mechanical properties and bioactivity of the final coating. Microindentations at the coating/substrate interface and tensile tests were performed to evaluate the bonding strength between the sample's components. In vitro bioactive behaviour was assessed by soaking in simulated body fluid and evaluating the apatite formation on the surface and inside the pores of the trabecular coating. The concepts disclosed in the present study can have a significant impact in the field of implantable devices, suggesting a valuable alternative to traditional, often invasive bone-prosthesis fixation.
本工作提出了将泡沫状玻璃陶瓷支架用作陶瓷假体的小梁涂层，以增强植入物的骨整合。通过简化的平面几何形状探索了这种创新装置的可行性：通过聚合物海绵复制制备的玻璃陶瓷支架，模仿松质骨的小梁结构，通过致密玻璃涂层（中间层）与氧化铝方形基底连接。研究了起始玻璃的不同配方的作用，特别关注对最终涂层的机械性能和生物活性的影响。在涂层/基底界面处进行微压痕和拉伸测试，以评估样品各组成部分之间的结合强度。通过在模拟体液中浸泡并评估小梁涂层的表面和内部孔隙中的磷灰石形成来评估体外生物活性行为。本研究中揭示的概念在植入式装置领域具有重大影响，为传统的、通常是侵入性的骨-假体固定提供了一种有价值的替代方案。
