Politecnico di Torino, Department of Applied Science and Technology, Torino, Corso Duca degli Abruzzi 24, 10129 Torino, Italy.
Centre CIM/Departament d'Enginyeria Mecànica, Universitat Politècnica de Catalunya, Av. Diagonal, 647, 08028 Barcelona, Spain.
Int J Mol Sci. 2019 Feb 8;20(3):722. doi: 10.3390/ijms20030722.
Achieving the stable osteointegration of prosthetic implants is one of the great challenges of modern orthopedic surgery. The fixation of ceramic acetabular cups of hip joint prostheses is usually achieved using a metal shell provided with screws or pegs that penetrate into the host pelvic bone. The deposition of bioactive coatings on the implant surface to be put in contact with bone could be a valuable strategy to promote a more "physiological" osteointegration. In this work, bioactive glass porous coatings were manufactured on the top of alumina/zirconia composite implants by two different methods, i.e., sponge replication and laser cladding. The coated samples underwent immersion studies in Kokubo's simulated body fluid (SBF) to assess in vitro bioactivity and were found to exhibit an excellent hydroxyapatite-forming ability, which is key to allow bonding to bone. Biological tests using mesenchymal stem and osteoblast-like cells revealed the good biocompatibility of both types of materials. Furthermore, a higher level of mineralization was induced by the sponge-replicated coatings at 10 days. Overall, these results are highly promising and encourage further research on these materials.
实现假体植入物的稳定骨整合是现代骨科手术的重大挑战之一。髋关节假体的陶瓷髋臼杯的固定通常采用带有螺钉或销钉的金属外壳，这些螺钉或销钉穿透宿主骨盆骨。在要与骨接触的植入物表面沉积生物活性涂层可能是促进更“生理”骨整合的一种有价值的策略。在这项工作中，通过两种不同的方法，即在海绵复制和激光熔覆的基础上，在氧化铝/氧化锆复合材料植入物的顶部制造了生物活性玻璃多孔涂层。对涂覆的样品进行了在 Kokubo 模拟体液（SBF）中的浸泡研究，以评估体外生物活性，结果表明它们具有优异的羟基磷灰石形成能力，这是与骨结合的关键。使用间充质干细胞和成骨样细胞进行的生物学测试表明，这两种材料均具有良好的生物相容性。此外，在第 10 天时，海绵复制涂层诱导了更高水平的矿化。总的来说，这些结果非常有希望，并鼓励对这些材料进行进一步的研究。
