Kambam J R, Parris W C, Naukam R J, Franks J J, Sastry B V
Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee 37232-2125.
Can J Anaesth. 1990 Nov;37(8):916-9. doi: 10.1007/BF03006636.
The in vitro effects of two metabolites of inhalational anaesthetics, fluoride and bromide, on pseudocholinesterase (PCHE) and acetylcholinesterase (ACHE) activities in the blood samples of seven healthy patients were studied. The PCHE and ACHE activities were determined by kinetic spectrophotometric methods. Fluoride at the levels achieved with clinical concentrations of enflurane and sevoflurane (25-75 microM.L-1) inhibited PCHE activity by 28-65 per cent (P less than 0.01) and ACHE activity by less than five per cent (P greater than 0.05). Bromide at the levels achieved with clinical concentrations of inhalational anaesthetics had no significant effect on either PCHE or ACHE activity. We recommend caution when succinylcholine and/or ester type local anaesthetics are used in the immediate postoperative period following enflurane or sevoflurane anaesthesia. We also recommend that blood drawing for PCHE activity be delayed at least until 24 hr following enflurane or sevoflurane anaesthesia.
研究了吸入麻醉剂的两种代谢产物氟化物和溴化物对7名健康患者血样中假性胆碱酯酶（PCHE）和乙酰胆碱酯酶（ACHE）活性的体外影响。通过动力学分光光度法测定PCHE和ACHE活性。临床浓度的恩氟烷和七氟烷所达到的氟化物水平（25 - 75微摩尔/升）使PCHE活性抑制28% - 65%（P < 0.01），而使ACHE活性抑制小于5%（P > 0.05）。临床浓度吸入麻醉剂所达到的溴化物水平对PCHE或ACHE活性均无显著影响。我们建议在恩氟烷或七氟烷麻醉后的术后即刻使用琥珀酰胆碱和/或酯类局部麻醉剂时要谨慎。我们还建议，至少在恩氟烷或七氟烷麻醉后24小时再进行血样采集以测定PCHE活性。
