Roboz J, Kappatos D, Holland J F
Department of Neoplastic Diseases, Mount Sinai School of Medicine, New York, NY 10029.
Clin Chem. 1990 Dec;36(12):2082-6.
Polyol concentrations were determined by selected-ion monitoring in 10 sample sets taken before dialysis and hourly for 4 h during dialysis. Predialysis concentrations (mumol/L) exceeding the upper limit of normal (mean + 2 SD; n = 33) were found for erythritol (25.4-59.0), threitol (11.5-46.7), and arabinitol (21.0-49.3) in all 10 cases; mannitol (2.7-62.0) in nine cases; and xylitol (0.7-1.3) in eight cases. Concentrations of adonitol, galactitol, and sorbitol were all within normal limits. During dialysis, the concentration of six polyols decreased by approximately 50%, but there were no significant changes for xylitol and adonitol. Erythritol, threitol, and arabinitol concentrations remained more than double the upper limit of normal in all patients after 4 h of dialysis. High residual concentrations were found for mannitol (seven cases) and xylitol (six cases). The results suggest fundamental differences in the homeostasis as well as the dialyzability of different polyols. The potential toxic significance of the high residual concentrations after a 4-h dialysis needs to be investigated.
通过选择离子监测法测定了10组样本中的多元醇浓度，这些样本在透析前采集，并在透析期间每小时采集一次，共采集4小时。在所有10例病例中，透析前赤藓糖醇（25.4 - 59.0）、苏糖醇（11.5 - 46.7）和阿拉伯糖醇（21.0 - 49.3）的浓度（微摩尔/升）超过正常上限（均值 + 2标准差；n = 33）；9例中甘露醇（2.7 - 62.0）浓度超标；8例中木糖醇（0.7 - 1.3）浓度超标。核糖醇、半乳糖醇和山梨醇的浓度均在正常范围内。透析期间，六种多元醇的浓度下降了约50%，但木糖醇和核糖醇没有显著变化。透析4小时后，所有患者体内的赤藓糖醇、苏糖醇和阿拉伯糖醇浓度仍超过正常上限两倍以上。甘露醇（7例）和木糖醇（6例）存在高残留浓度。结果表明不同多元醇在体内稳态以及透析性方面存在根本差异。4小时透析后高残留浓度的潜在毒性意义需要进一步研究。
