Servo C, Palo J, Pitkänen E
Acta Neurol Scand. 1977 Aug;56(2):104-10. doi: 10.1111/j.1600-0404.1977.tb01415.x.
Seven polyols, erythritol, arabinitol, anhydroflucitol, mannitol, sorbitol, myoinositol and possibly ribitol were identified in human cerebrospinal fluid by means of gas-liquid chromatography and mass spectrometry. Quantitative data were obtained for five polyols, arabinitol, anhydroglucitol, mannitol, sorbitol and myoinositol, by screening of 205 CSF samples. These five polyols represented 90-95 per cent of the polyol-concentration which was 340 +/- 105 mumol/1 in the total series. The concentration of polyols in the CSF was two times higher than that in the plasma (148 +/- 30 mumol/1), where only anhydroglucitol and myoinositol could be quantitated. The variations noted were not associated with age, sex or the plasma concentrations of polyols. The polyols of the CSF most likely originate from brain tissue and/or spinal cord since penetration from the plasma against a gradient seems unlikely.
通过气液色谱法和质谱法在人类脑脊液中鉴定出七种多元醇，即赤藓糖醇、阿拉伯糖醇、脱水葡糖醇、甘露醇、山梨醇、肌醇以及可能的核糖醇。通过对205份脑脊液样本进行筛查，获得了五种多元醇（阿拉伯糖醇、脱水葡糖醇、甘露醇、山梨醇和肌醇）的定量数据。这五种多元醇占多元醇浓度的90 - 95%，在整个样本系列中多元醇浓度为340±105μmol/L。脑脊液中多元醇的浓度比血浆（148±30μmol/L）中的浓度高两倍，血浆中只能对脱水葡糖醇和肌醇进行定量。观察到的这些变化与年龄、性别或血浆中多元醇的浓度无关。脑脊液中的多元醇很可能源自脑组织和/或脊髓，因为从血浆逆浓度梯度渗透似乎不太可能。
