Zhou Xin, Wu Chengyi
Department of Endocrine and Breast Surgery, First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2012 Mar;37(3):238-43. doi: 10.3969/j.issn.1672-7347.2012.03.005.
To evaluate the correlations between p73 G4C14-A4T14 polymorphisms and clinicopathologic characteristics of patients with breast cancer.
A total of 170 patients with breast cancer were genotyped for p73 G4C14-A4T14 polymorphisms by Sequenom MassArray® iPLEX GOLD System. The correlations between polymorphisms and the age of patients with breast cancer, or tumor size were analyzed by t-test;the correlations between polymorphisms and clinicopathologic characteristics in patients with breast cancer were analyzed by Χ(2) test; and the relation between polymorphisms and the efficacy of chemotherapy for breast cancer was assessed by logistic regression.
There was negative correlation between p73 polymorphisms and ser veral clinicopathological characteristics, including age, tumor size, menopausal status, TNM classification, pathological type, axillary lymph node metastasis, estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2, and p53(P>0.05). The frequency of GC/GC genotype in patients with "triple negative" breast cancer (estrogen receptor -negative, progesterone receptornegative, and human epidermal growth factor receptor 2-negative) was higher than that of patients with non-triple negative breast cancer (78.9% vs 57.6%, Χ(2)=5.741, P=0.017). P73 polymorphism was negatively correlated with chemosensitivity for anthracycline-based chemotherapy (P>0.05).
P73 G4C14-A4T14 polymorphisms are positively correlated with triple negative breast cancer, and the patients with breast cancer who carry GC/GC genotype may have bad prognosis.
评估p73基因G4C14-A4T14多态性与乳腺癌患者临床病理特征之间的相关性。
采用Sequenom MassArray® iPLEX GOLD系统对170例乳腺癌患者的p73基因G4C14-A4T14多态性进行基因分型。采用t检验分析多态性与乳腺癌患者年龄、肿瘤大小的相关性；采用χ²检验分析多态性与乳腺癌患者临床病理特征的相关性；采用logistic回归评估多态性与乳腺癌化疗疗效的关系。
p73基因多态性与年龄、肿瘤大小、绝经状态、TNM分期、病理类型、腋窝淋巴结转移、雌激素受体、孕激素受体、人表皮生长因子受体2及p53等多项临床病理特征呈负相关（P>0.05）。“三阴性”乳腺癌（雌激素受体阴性、孕激素受体阴性、人表皮生长因子受体2阴性）患者中GC/GC基因型频率高于非三阴性乳腺癌患者（78.9%比57.6%，χ²=5.741，P=0.017）。p73基因多态性与蒽环类化疗的化疗敏感性呈负相关（P>0.05）。
P73基因G4C14-A4T14多态性与三阴性乳腺癌呈正相关，携带GC/GC基因型的乳腺癌患者预后可能较差。
