Halme L, von Knorring J, Elonen E
Fourth Department of Surgery, Helsinki University Central Hospital, Finland.
Dig Dis Sci. 1990 Dec;35(12):1553-6. doi: 10.1007/BF01540575.
In our hospital within one year two patients with Crohn's disease were seen who developed an acute myelocytic leukemia. A review of the literature reveals eight previously reported patients with both Crohn's disease and leukemia. Six of the reported 10 patients have had acute myelocytic leukemia and, interestingly, three of them, including our two patients, have shown monocytic differentiation (FAB type M4). It has been suggested that the relative risk of leukemia, especially acute myelocytic leukemia, is increased in patients suffering from ulcerative colitis. More data of patients with Crohn's disease and acute leukemia are needed to evaluate the possible association between these diseases.
在我们医院，一年之内有两名克罗恩病患者被诊断出患有急性髓细胞白血病。文献回顾显示，之前有八名患者同时患有克罗恩病和白血病。在已报告的10名患者中，有6名患有急性髓细胞白血病，有趣的是，其中3名患者，包括我们的两名患者，表现出单核细胞分化（FAB分型为M4型）。有人提出，溃疡性结肠炎患者患白血病尤其是急性髓细胞白血病的相对风险会增加。需要更多克罗恩病和急性白血病患者的数据来评估这些疾病之间可能存在的关联。
