Peterson M E, Gamble D A
Department of Medicine, Animal Medical Center, New York, NY.
J Am Vet Med Assoc. 1990 Nov 1;197(9):1203-8.
We reviewed the medical records of 494 cats with a variety of nonthyroidal diseases in which serum thyroxine (T4) concentration was determined as part of diagnostic evaluation. The cats were grouped by category of disease (ie, renal disease, congestive heart failure, diabetes mellitus, focal neoplasia, systemic neoplasia, hepatopathy, inflammatory bowel disease, inflammatory pulmonary disease, miscellaneous diseases, or undiagnosed disease), degree of illness (ie, mild, moderate, or severe), survival (ie, lived, died, or euthanatized), and presence or absence of a palpable thyroid gland. The mean (+/- SD) serum T4 concentrations in all 10 groups of cats, which ranged from 10.5 +/- 11.1 nmol/L in cats with diabetes mellitus to 18.7 +/- 7.8 nmol/L in cats with focal neoplasia, were significantly (P less than 0.001) lower than those of normal cats (27.0 +/- 10.4 nmol/L). The number of ill cats with low serum T4 concentrations (less than 10 nmol/L) was highest in the cats with diabetes mellitus (59%), hepatopathy (54%), renal failure (48%), and systemic neoplasia (41%). When the serum T4 concentrations in cats with mild, moderate, and severe illness were compared, mean concentrations were progressively lower (21.3 +/- 6.8, 14.8 +/- 8.1, and 6.5 +/- 5.8 nmol/L, respectively) as degree of illness increased. Severity of illness had a more significant (P less than 0.001) effect in lowering serum T4 concentrations than did disease category. Mean serum T4 concentrations in the cats that died (7.8 +/- 9.8 nmol/L) or were euthanatized (10.0 +/- 7.0 nmol/L) were also significantly (P less than 0.001) lower than those of cats that survived (15.2 +/- 8.8 nmol/L).(ABSTRACT TRUNCATED AT 250 WORDS)
我们回顾了494只患有各种非甲状腺疾病猫的病历，这些猫的血清甲状腺素（T4）浓度作为诊断评估的一部分进行了测定。这些猫按疾病类别（即肾病、充血性心力衰竭、糖尿病、局灶性肿瘤、全身性肿瘤、肝病、炎症性肠病、炎症性肺病、杂病或未确诊疾病）、疾病程度（即轻度、中度或重度）、存活情况（即存活、死亡或安乐死）以及是否可触及甲状腺进行分组。所有10组猫的平均（±标准差）血清T4浓度范围为，糖尿病猫为10.5±11.1nmol/L，局灶性肿瘤猫为18.7±7.8nmol/L，均显著低于正常猫（27.0±10.4nmol/L）（P<0.001）。血清T4浓度低（低于10nmol/L）的患病猫数量在糖尿病猫（59%）、肝病猫（54%）、肾衰竭猫（48%）和全身性肿瘤猫（41%）中最多。比较轻度、中度和重度疾病猫的血清T4浓度时，随着疾病程度增加，平均浓度逐渐降低（分别为21.3±6.8、14.8±8.1和6.5±5.8nmol/L）。疾病严重程度对降低血清T4浓度的影响比疾病类别更显著（P<0.001）。死亡猫（7.8±9.8nmol/L）或安乐死猫（10.0±7.0nmol/L）的平均血清T4浓度也显著低于存活猫（15.2±8.8nmol/L）（摘要截短至250字）
