Division of Hepatology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Clin Liver Dis. 2012 May;16(2):387-96. doi: 10.1016/j.cld.2012.03.013.
Hepatic granulomata are not infrequently encountered in liver biopsy and often are associated with systemic disease. The clinical presentation varies with the particular systemic process. From a biochemical standpoint, the most common abnormalities are elevated serum alkaline phosphatase and γ-glutamyltransferase. The observation of granulomata in a liver biopsy specimen warrants workup to identify a possible cause. Clues may be obtained in the medical history, on physical examination, or with specialized blood testing or radiologic studies. Treatment involves therapy of the underlying cause of the disease associated with the development of the granulomatous hepatitis.
肝肉芽肿在肝活检中并不少见，通常与全身性疾病有关。临床表现因特定的全身过程而异。从生化角度来看，最常见的异常是血清碱性磷酸酶和γ-谷氨酰转移酶升高。肝活检标本中观察到肉芽肿提示需要进行检查以确定可能的原因。病史、体格检查或特殊的血液检查或影像学研究可能会提供线索。治疗包括针对与肉芽肿性肝炎相关的疾病的根本原因进行治疗。
