蜂房芽孢杆菌的硫醇激活毒素蜂房溶素与李斯特菌溶血素O、产气荚膜梭菌溶血素O、肺炎溶血素和链球菌溶血素O同源，且含有一个半胱氨酸。
Alveolysin, the thiol-activated toxin of Bacillus alvei, is homologous to listeriolysin O, perfringolysin O, pneumolysin, and streptolysin O and contains a single cysteine.
作者信息
Geoffroy C, Mengaud J, Alouf J E, Cossart P
机构信息
Centre National de la Recherche Scientifique Unité Associée 557, Institut Pasteur, Paris, France.
出版信息
J Bacteriol. 1990 Dec;172(12):7301-5. doi: 10.1128/jb.172.12.7301-7305.1990.
Abstract
The gene coding for alveolysin, the thiol-activated toxin produced by Bacillus alvei, has been cloned by means of an oligonucleotide based on the known N-terminal sequence of the secreted protein. The complete nucleotide sequence of the gene has been determined. The deduced amino acid sequence of alveolysin shows that alveolysin shares homologies with listeriolysin O, perfringolysin O, pneumolysin, and streptolysin O. Alveolysin, like the other members of the family, contains a single cysteine in the conserved peptide sequence ECTGLA WEWWR.
摘要
编码蜂房芽孢杆菌产生的硫醇激活毒素蜂房溶素的基因，已通过基于该分泌蛋白已知N端序列的寡核苷酸进行克隆。该基因的完整核苷酸序列已确定。蜂房溶素推导的氨基酸序列表明，蜂房溶素与李斯特菌溶血素O、产气荚膜梭菌溶血素O、肺炎链球菌溶血素和链球菌溶血素O具有同源性。与该家族的其他成员一样，蜂房溶素在保守肽序列ECTGLA WEWWR中含有一个半胱氨酸。
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Alveolysin, the thiol-activated toxin of Bacillus alvei, is homologous to listeriolysin O, perfringolysin O, pneumolysin, and streptolysin O and contains a single cysteine.蜂房芽孢杆菌的硫醇激活毒素蜂房溶素与李斯特菌溶血素O、产气荚膜梭菌溶血素O、肺炎溶血素和链球菌溶血素O同源，且含有一个半胱氨酸。
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