School of Ophthalmology and Optometry, Wenzhou Medical College, Zhejiang, China.
Eye Contact Lens. 2012 May;38(3):183-7. doi: 10.1097/ICL.0b013e318252ce0c.
To determine the relationships among tear menisci variables and clinical tests used in the diagnosis of dry eye patients.
Dry eye patients (n=50; age, 35.2 years) and healthy subjects (n=48; age, 33.3 years) were recruited. Upper and lower tear menisci were imaged noninvasively by optical coherence tomography (OCT) immediately after normal and delayed blinking in both eyes. Tear meniscus heights, areas, and radius of curvatures were obtained by custom software. Tear film break-up time was measured by fluorescein (fluorescein film tear break-up time, FTBUT) and tearscope (noninvasive tear film break-up time), ocular surface vital staining was evaluated with fluorescein (FS), and secretion was measured by Schirmer I test without and with anesthesia.
In dry eye patients, all lower tear meniscus variables during normal blinking were correlated with all clinical tests except Schirmer I test without anesthesia. Upper tear meniscus variables were correlated with FTBUT and Schirmer I test with anesthesia. During delayed blinking, upper and lower tear menisci variables were correlated with Schirmer I test without anesthesia and FS; however, there were no correlations between menisci variables and FTBUT or Schirmer I test with anesthesia. In healthy subjects, only lower meniscus variables were correlated with Schirmer I test with anesthesia during normal blinking. During delayed blinking, the lower meniscus variables were correlated with only the Schirmer I test without anesthesia.
Lower tear menisci were correlated more strongly with the clinical tests than were upper menisci. The tear menisci were associated with the basic tear secretion during normal blinking. Delayed blinking may affect reflex tearing levels.
确定泪膜半月板变量与用于诊断干眼症患者的临床检查之间的关系。
招募干眼症患者（n=50；年龄，35.2 岁）和健康受试者（n=48；年龄，33.3 岁）。使用光学相干断层扫描（OCT）在双眼正常和延迟眨眼后立即对上下泪膜半月板进行非侵入性成像。通过定制软件获得泪膜半月板高度、面积和曲率半径。使用荧光素（荧光素膜破裂时间，FTBUT）和泪膜镜（非侵入性泪膜破裂时间）测量泪膜破裂时间，用荧光素评估眼表面生命染色（FS），并用 Schirmer I 试验（无麻醉）和 Schirmer I 试验（麻醉）测量分泌。
在干眼症患者中，正常眨眼时所有下泪膜半月板变量均与除 Schirmer I 试验（无麻醉）外的所有临床检查相关。上泪膜半月板变量与 FTBUT 和 Schirmer I 试验（麻醉）相关。在延迟眨眼期间，上、下泪膜半月板变量与 Schirmer I 试验（无麻醉）和 FS 相关；然而，半月板变量与 FTBUT 或 Schirmer I 试验（麻醉）之间没有相关性。在健康受试者中，只有在正常眨眼时，下半月板变量才与 Schirmer I 试验（麻醉）相关。在延迟眨眼期间，下半月板变量仅与 Schirmer I 试验（无麻醉）相关。
下泪膜半月板与临床检查的相关性强于上泪膜半月板。泪膜半月板与正常眨眼时的基础泪液分泌有关。延迟眨眼可能会影响反射性流泪水平。
