Wang Jianhua, Palakuru Jayachandra R, Aquavella James V
Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami, Miami, Florida 33136, USA.
Am J Ophthalmol. 2008 May;145(5):795-800. doi: 10.1016/j.ajo.2007.12.035. Epub 2008 Mar 10.
To determine the relationships among tear meniscus parameters, noninvasive tear break-up time (NITBUT), and the Schirmer test.
Experimental study.
Thirty-six subjects were tested on one randomly selected eye. Real-time corneal optical coherence tomography (OCT) was used to image the upper and lower tear menisci during normal and delayed blinking followed by measurement of NITBUT and the Schirmer test. Digital images of the eye were taken for measuring the lid lengths to estimate tear volume in the menisci.
Compared with normal blinking, significant increases of tear menisci occurred during delayed blinking (post hoc, P < .01). NITBUT was weakly but significantly correlated with the height (r = 0.36; P = .03) and area (r = 0.37; P = .03) of the lower tear meniscus during normal blinks. NITBUT was also correlated with the lower tear meniscus volume (r = 0.45; P < .05) and total tear meniscus volume (r = 0.43; P < .05) during normal blinking. The Schirmer test was not significantly related to any parameters of the tear menisci, volumes, or NITBUT; however, it was negatively correlated with the age of the subjects (r = -0.47; P = .004). The age was negatively correlated with the upper tear meniscus (r ranged from 0.36 to 0.37 for the radius, height, and area, P < .05) measured during delayed blinking.
NITBUT appears correlated with the lower tear meniscus during normal blinking, and the Schirmer test appears not correlated with the noninvasively measured tear meniscus.
确定泪液半月皱襞参数、无创泪膜破裂时间（NITBUT）和Schirmer试验之间的关系。
实验研究。
对36名受试者随机选择的一只眼睛进行测试。使用实时角膜光学相干断层扫描（OCT）在正常眨眼和延迟眨眼期间对上下泪液半月皱襞进行成像，随后测量NITBUT和Schirmer试验。拍摄眼睛的数字图像以测量睑裂长度，从而估计半月皱襞中的泪液量。
与正常眨眼相比，延迟眨眼期间泪液半月皱襞显著增加（事后检验，P <.01）。在正常眨眼期间，NITBUT与下泪液半月皱襞的高度（r = 0.36；P = .03）和面积（r = 0.37；P = .03）呈弱但显著的相关性。在正常眨眼期间，NITBUT还与下泪液半月皱襞体积（r = 0.45；P <.05）和总泪液半月皱襞体积（r = 0.43；P <.05）相关。Schirmer试验与泪液半月皱襞的任何参数、体积或NITBUT均无显著相关性；然而，它与受试者的年龄呈负相关（r = -0.47；P = .004）。年龄与延迟眨眼期间测量的上泪液半月皱襞（半径、高度和面积的r范围为0.36至0.37，P <.05）呈负相关。
在正常眨眼期间，NITBUT似乎与下泪液半月皱襞相关，而Schirmer试验似乎与无创测量的泪液半月皱襞无关。
