Cui Lele, Shen Meixiao, Wang Jianhua, Jiang Jun, Li Ming, Chen Ding, Chen Zhao, Tao Aizhu, Lu Fan
School of Ophthalmology and Optometry, Wenzhou Medical College, Wenzhou, Zhejiang, China.
Optom Vis Sci. 2011 Oct;88(10):1214-9. doi: 10.1097/OPX.0b013e3182271297.
To determine age-related changes of tear menisci in healthy subjects and to compare tear variables between age-matched normals and dry eye subjects.
Anterior segment optical coherence tomography was used to measure upper and lower tear menisci in healthy subjects (n = 197, 8-83 years) and in age-matched dry eye patients (n = 38, 19-72 years). Measured tear variables included the height and area of the tear meniscus. Tear meniscus volumes were calculated based on the cross-sectional areas of the tear menisci and the eyelid lengths. The age-related decrease rates of the tear menisci were also calculated.
There were significant negative correlations between age and all tear meniscus dimensions (r ranged from -0.649 to -0.753; p < 0.05) in the healthy group. The rate of decrease for the total tear meniscus volume in healthy subjects was 1.0% per year. Compared with age-matched healthy subjects, the height, cross-sectional area, and volume of the upper and lower tear menisci in dry eye subjects were significantly smaller (p < 0.05).
Tear menisci decreased with age in the healthy group. The variables in age-matched dry eye subjects were significantly lower than those in the healthy group.
确定健康受试者泪液半月皱襞的年龄相关性变化，并比较年龄匹配的正常人与干眼受试者的泪液相关变量。
采用眼前节光学相干断层扫描技术测量健康受试者（n = 197，年龄8 - 83岁）和年龄匹配的干眼患者（n = 38，年龄19 - 72岁）的上下泪液半月皱襞。测量的泪液相关变量包括泪液半月皱襞的高度和面积。根据泪液半月皱襞的横截面积和睑裂长度计算泪液半月皱襞体积。还计算了泪液半月皱襞的年龄相关性下降率。
在健康组中，年龄与所有泪液半月皱襞尺寸之间存在显著的负相关（r范围为 - 0.649至 - 0.753；p < 0.05）。健康受试者的总泪液半月皱襞体积每年下降率为1.0%。与年龄匹配的健康受试者相比，干眼受试者的上下泪液半月皱襞的高度、横截面积和体积均显著较小（p < 0.05）。
健康组中泪液半月皱襞随年龄增长而减少。年龄匹配的干眼受试者的相关变量显著低于健康组。
