Barratt C L, Bolton A E, Cooke I D
Harris Birthright Centre for Reproductive Medicine, University Department of Obstetrics and Gynaecology, Jessop Hospital for Women, Sheffield, UK.
Hum Reprod. 1990 Aug;5(6):639-48. doi: 10.1093/oxfordjournals.humrep.a137162.
The functional significance of white blood cells in the modulation of an anti-sperm antibody response, prevention of infection (including HIV) sperm transport/storage and sperm function is extensively discussed. A critical review of the existing literature is presented with future experimental lines of investigation outlined. A lack of controlled clinical studies in the human to validate data from animal species--for example--the involvement of white blood cells in the transport and storage of sperm in the female tract and the possible adverse effect of pathology (i.e. endometriosis) on these functions are presented. In conclusion, with the advent of modern techniques, e.g. monoclonal antibodies and sophisticated sperm function tests, many of the questions raised should be answered in the near future.
本文广泛讨论了白细胞在调节抗精子抗体反应、预防感染（包括艾滋病毒）、精子运输/储存及精子功能方面的功能意义。对现有文献进行了批判性综述，并概述了未来的实验研究方向。文中指出，缺乏人体对照临床研究来验证动物实验数据，例如白细胞在女性生殖道中精子运输和储存中的作用，以及病理状况（如子宫内膜异位症）对这些功能可能产生的不利影响。总之，随着现代技术的出现，如单克隆抗体和精密的精子功能测试，许多提出的问题在不久的将来应该能够得到解答。
