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Development and application of a broadly sensitive dried-blood-spot-based genotyping assay for global surveillance of HIV-1 drug resistance.一种广泛敏感的基于干血斑的基因分型检测方法的开发和应用，用于全球监测 HIV-1 耐药性。
J Clin Microbiol. 2010 Sep;48(9):3158-64. doi: 10.1128/JCM.00564-10. Epub 2010 Jul 21.
2
Characterization of HIV type 1 genotypes and drug resistance mutations among drug-naive HIV type 1-infected patients in Northern Vietnam.越南北方初治的1型艾滋病毒感染患者中1型艾滋病毒基因型及耐药突变特征分析
AIDS Res Hum Retroviruses. 2010 Feb;26(2):233-5. doi: 10.1089/aid.2009.0206.
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Low prevalence of HIV type 1 drug resistance mutations in untreated, recently infected patients from Burkina Faso, Côte d'Ivoire, Senegal, Thailand, and Vietnam: the ANRS 12134 study.来自布基纳法索、科特迪瓦、塞内加尔、泰国和越南的未经治疗的近期感染患者中，1型艾滋病毒耐药性突变的低流行率：法国国家艾滋病研究机构12134研究
AIDS Res Hum Retroviruses. 2009 Nov;25(11):1193-6. doi: 10.1089/aid.2009.0142.
4
Dried fluid spots for HIV type-1 viral load and resistance genotyping: a systematic review.用于1型人类免疫缺陷病毒病毒载量和耐药基因分型的干血斑：一项系统评价
Antivir Ther. 2009;14(5):619-29.
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The calibrated population resistance tool: standardized genotypic estimation of transmitted HIV-1 drug resistance.校准后的群体耐药性工具：传播的HIV-1耐药性的标准化基因型估计
Bioinformatics. 2009 May 1;25(9):1197-8. doi: 10.1093/bioinformatics/btp134. Epub 2009 Mar 20.
6
Drug resistance mutations for surveillance of transmitted HIV-1 drug-resistance: 2009 update.用于监测传播的HIV-1耐药性的耐药性突变：2009年更新
PLoS One. 2009;4(3):e4724. doi: 10.1371/journal.pone.0004724. Epub 2009 Mar 6.
7
Profile of HIV type 1 infection and genotypic resistance mutations to antiretroviral drugs in treatment-naive HIV type 1-infected individuals in Hai Phong, Viet Nam.越南海防市初治的1型人类免疫缺陷病毒（HIV-1）感染者中1型HIV感染情况及抗逆转录病毒药物基因型耐药突变分析
AIDS Res Hum Retroviruses. 2009 Feb;25(2):175-82. doi: 10.1089/aid.2008.0193.
8
HIV drug resistance threshold survey using specimens from voluntary counselling and testing sites in Hanoi, Vietnam.利用越南河内自愿咨询和检测点的样本进行的艾滋病毒耐药性阈值调查。
Antivir Ther. 2008;13 Suppl 2:115-21.
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A novel sequential sampling technique for the surveillance of transmitted HIV drug resistance by cross-sectional survey for use in low resource settings.一种用于在资源匮乏地区通过横断面调查监测传播的HIV耐药性的新型序贯抽样技术。
Antivir Ther. 2008;13 Suppl 2:37-48.
10
HIV-1 drug resistance surveillance using dried whole blood spots.使用干血斑进行HIV-1耐药性监测。
Antivir Ther. 2007;12(1):107-13.

2007-2008 年越南胡志明市自愿咨询检测点血浆和干血斑标本中传播的 HIV 耐药性监测。

Surveillance of transmitted HIV drug resistance using matched plasma and dried blood spot specimens from voluntary counseling and testing sites in Ho Chi Minh City, Vietnam, 2007-2008.

机构信息

Department of Health and Human Services/US Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.

出版信息

Clin Infect Dis. 2012 May;54 Suppl 4(Suppl 4):S343-7. doi: 10.1093/cid/cir1049.

DOI:10.1093/cid/cir1049
PMID:22544201
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3572868/
Abstract

During 2007-2008, surveillance of transmitted human immunodeficiency virus (HIV) drug resistance (TDR) was performed following World Health Organization guidance among clients with newly diagnosed HIV infection attending voluntary counseling and testing (VCT) sites in Ho Chi Minh City (HCMC), Vietnam. Moderate (5%-15%) TDR to nonnucleoside reverse-transcriptase inhibitors (NNRTIs) was observed among VCT clients aged 18-21 years. Follow-up surveillance of TDR in HCMC and other geographic regions of Vietnam is warranted. Data generated will guide the national HIV drug resistance surveillance strategy and support selection of current and future first-line antiretroviral therapy and HIV prevention programs.

摘要

2007-2008 年，根据世界卫生组织的指导，在越南胡志明市接受自愿咨询检测（VCT）服务的新诊断感染艾滋病毒的患者中，对传播的人类免疫缺陷病毒（HIV）耐药性（TDR）进行了监测。在年龄为 18-21 岁的 VCT 患者中，观察到中度（5%-15%）对非核苷类逆转录酶抑制剂（NNRTIs）的耐药性。有必要对胡志明市和越南其他地区的 TDR 进行后续监测。所产生的数据将指导国家 HIV 耐药性监测策略，并支持当前和未来一线抗逆转录病毒治疗和艾滋病毒预防方案的选择。