Department of Otolaryngology-Head and Neck Surgery/Surgical Oncology, Wharton Head and Neck Program, University Health Network, Princess Margaret Hospital, Toronto, Ontario, Canada.
Head Neck. 2013 May;35(5):632-41. doi: 10.1002/hed.23001. Epub 2012 Apr 27.
The purpose of this study was to analyze the outcomes and treatment in patients with squamous cell carcinoma (SCC) of the oral tongue, as well as validate previously reported predictors of survival.
We retrospectively reviewed 259 patients treated with curative intent between 1994 and 2004. Kaplan-Meier estimates, log-rank test, and Cox regression models were used for statistical analysis.
Two hundred fifty-nine patients were managed with surgery; 67 patients (25%) received adjuvant radiotherapy. Mean follow-up was 60 months. The 5-year local and regional control rates were 78% and 69.4%, respectively. The 5-year overall, disease-specific, and recurrence-free survival rates were 69%, 70.9%, and 53%, respectively. The only significant predictor of both overall survival (OS) and disease-free survival (DFS) on multivariable analysis was pathologic N classification.
Treatment of early tongue SCC effectively achieves local control and DFS. Nodal disease remains to be 1 of the most important prognostic factors in terms of recurrence and survival.
本研究旨在分析口腔舌部鳞状细胞癌（SCC）患者的治疗效果，并验证先前报道的生存预测因素。
我们回顾性分析了 1994 年至 2004 年间接受根治性治疗的 259 例患者。采用 Kaplan-Meier 估计、对数秩检验和 Cox 回归模型进行统计分析。
259 例患者接受手术治疗，67 例（25%）患者接受辅助放疗。平均随访时间为 60 个月。5 年局部和区域控制率分别为 78%和 69.4%。5 年总生存率、疾病特异性生存率和无复发生存率分别为 69%、70.9%和 53%。多因素分析显示，病理 N 分期是总生存（OS）和无病生存（DFS）的唯一显著预测因素。
早期舌 SCC 的治疗可有效实现局部控制和 DFS。淋巴结疾病仍然是复发和生存的最重要的预后因素之一。
