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Single-molecule FRET reveals the folding dynamics of the human telomerase RNA pseudoknot domain.

作者信息

Hengesbach Martin, Kim Nak-Kyoon, Feigon Juli, Stone Michael D

机构信息

Department of Chemistry and Biochemistry, Center for Molecular Biology of RNA, University of California Santa Cruz, Santa Cruz, CA 95064, USA.

出版信息

Angew Chem Int Ed Engl. 2012 Jun 11;51(24):5876-9. doi: 10.1002/anie.201200526. Epub 2012 Apr 27.

Abstract
摘要

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本文引用的文献

1
Architecture of human telomerase RNA.
Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20325-32. doi: 10.1073/pnas.1100279108. Epub 2011 Aug 15.
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Functional importance of telomerase pseudoknot revealed by single-molecule analysis.
Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20339-44. doi: 10.1073/pnas.1017686108. Epub 2011 May 13.
3
Structurally conserved five nucleotide bulge determines the overall topology of the core domain of human telomerase RNA.
Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):18761-8. doi: 10.1073/pnas.1013269107. Epub 2010 Oct 21.
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Specificity and stoichiometry of subunit interactions in the human telomerase holoenzyme assembled in vivo.
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RNA conformation in catalytically active human telomerase.
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Solution structure and dynamics of the wild-type pseudoknot of human telomerase RNA.
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Triple-helix structure in telomerase RNA contributes to catalysis.
Nat Struct Mol Biol. 2008 Jun;15(6):634-40. doi: 10.1038/nsmb.1420. Epub 2008 May 25.
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Single-molecule mechanical unfolding and folding of a pseudoknot in human telomerase RNA.
RNA. 2007 Dec;13(12):2175-88. doi: 10.1261/rna.676707. Epub 2007 Oct 24.
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Stepwise protein-mediated RNA folding directs assembly of telomerase ribonucleoprotein.
Nature. 2007 Mar 22;446(7134):458-61. doi: 10.1038/nature05600. Epub 2007 Feb 25.
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A triple helix within a pseudoknot is a conserved and essential element of telomerase RNA.
Mol Cell Biol. 2007 Mar;27(6):2130-43. doi: 10.1128/MCB.01826-06. Epub 2007 Jan 8.

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