面向多样性的合成：喜树碱和柯楠碱生物碱新型衍生物的简洁合成方法
Diversity Oriented Synthesis: Concise Entry to Novel Derivatives of Yohimbine and Corynanthe Alkaloids.
作者信息
Wang Zhiqian, Kaneda Kyosuke, Fang Zhenglai, Martin Stephen F
机构信息
Department of Chemistry and Biochemistry and Texas Institute for Drug and Diagnostic Development, The University of Texas, Austin, TX, 78712, USA.
出版信息
Tetrahedron Lett. 2012 Feb 1;53(5):477-479. doi: 10.1016/j.tetlet.2011.10.115. Epub 2011 Oct 31.
Abstract
A novel MCAP-cycloaddition sequence has been applied to the facile synthesis of β-carboline intermediates to gain rapid access to novel derivatives of yohimbine-like and corynanthe-like compounds that may be easily diversified by cross-coupling reactions and N-derivatizations to generate small compound libraries.
摘要
一种新型的MCAP环加成序列已应用于β-咔啉中间体的简便合成，以便快速获得育亨宾样和可里那定样化合物的新型衍生物，这些衍生物可通过交叉偶联反应和N-衍生化轻松多样化，以生成小型化合物库。
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