Guven Kim, Gunning Peter, Fath Thomas
Bioarchitecture. 2011 Nov 1;1(6):284-289. doi: 10.4161/bioa.1.6.19336.
Synaptic function in the central nervous system (CNS) is highly dependent on a dynamic actin cytoskeleton in both the pre- and the postsynaptic compartment. Remodelling of the actin cytoskeleton is controlled by tropomyosins, a family of actin-associated proteins which define distinct actin filament populations. Here we show that TPM3 and TPM4 gene products localize to the postsynaptic region in mouse hippocampal neurons. Furthermore our data confirm previous findings of isoform segregation to the pre- and postsynaptic compartments at CNS synapses. These data provide fundamental insights in the formation of functionally distinct actin filament populations at the pre- and post-synapse.
中枢神经系统（CNS）中的突触功能高度依赖于突触前和突触后区室中动态的肌动蛋白细胞骨架。肌动蛋白细胞骨架的重塑由原肌球蛋白控制，原肌球蛋白是一类与肌动蛋白相关的蛋白质家族，可定义不同的肌动蛋白丝群体。在这里，我们表明TPM3和TPM4基因产物定位于小鼠海马神经元的突触后区域。此外，我们的数据证实了先前关于异构体在中枢神经系统突触的突触前和突触后区室中分离的发现。这些数据为在突触前和突触后形成功能不同的肌动蛋白丝群体提供了基本见解。
