Department of Neurology, the University of Chicago, Chicago, IL, USA.
J Peripher Nerv Syst. 2012 May;17 Suppl 2:28-33. doi: 10.1111/j.1529-8027.2012.00392.x.
Autoimmune neuropathies comprise a diverse group of conditions resulting from an immune attack on the peripheral nervous system. In some of these disorders, the antigenic target has been identified. In other conditions such as chronic inflammatory demyelinating polyradiculoneuropathy, the initial trigger and the antigenic target remain elusive. Animal models have provided some important information regarding their pathogenetic mechanisms. This review summarizes the background information and recent highlights from studies in animal models such as experimental autoimmune neuritis and spontaneous autoimmune polyneuropathy in B7-2 knockout non-obese diabetic mice.
自身免疫性神经病变包括一组由针对周围神经系统的免疫攻击引起的多种疾病。在这些疾病中，一些抗原靶标已经确定。在其他疾病中，如慢性炎症性脱髓鞘性多发性神经病，初始触发因素和抗原靶标仍然难以捉摸。动物模型为其发病机制提供了一些重要信息。这篇综述总结了背景信息和来自动物模型研究的最新亮点，如实验性自身免疫性神经炎和 B7-2 敲除非肥胖型糖尿病小鼠自发性自身免疫性多发性神经病。
