Brabb Thea, Carbone Larry, Snyder Jessica, Phillips Nona
ILAR J. 2014;54(3):329-37. doi: 10.1093/ilar/ilt045.
Peripheral neuropathy and neuropathic pain are debilitating, life-altering conditions that affect a significant proportion of the human population. Animal models, used to study basic disease mechanisms and treatment modalities, are diverse and provide many challenges for institutional animal care and use committee (IACUC) review and postapproval monitoring. Items to consider include regulatory and ethical imperatives in animal models that may be designed to study pain, the basic mechanism of neurodegeneration, and different disease processes for which neuropathic pain is a side effect. Neuropathic pain can be difficult to detect or quantify in many models, and pain management is often unsuccessful in both humans and animals, inspiring the need for more research. Design of humane endpoints requires clear communication of potential adverse outcomes and solutions. Communication with the IACUC, researchers, and veterinary staff is also key for successful postapproval monitoring of these challenging models.
周围神经病变和神经性疼痛是使人衰弱、改变生活的病症，影响着相当一部分人群。用于研究基本疾病机制和治疗方式的动物模型多种多样，给机构动物护理和使用委员会（IACUC）的审查及批准后监测带来了诸多挑战。需要考虑的事项包括动物模型中的监管和伦理要求，这些模型可能旨在研究疼痛、神经退行性变的基本机制以及以神经性疼痛为副作用的不同疾病过程。在许多模型中，神经性疼痛可能难以检测或量化，而且疼痛管理在人类和动物中往往都不成功，这激发了更多研究的需求。人道终点的设计需要明确传达潜在的不良后果及解决方案。与IACUC、研究人员和兽医工作人员的沟通也是对这些具有挑战性的模型进行成功的批准后监测的关键。
