-的基因变异在支气管哮喘患者中的作用。 （你提供的原文“Role of genetic variations of - ”这里“-”指代不明，以上是按常规理解翻译）
Role of genetic variations of - in bronchial asthmatic patients.
作者信息
Abe Kazuyuki, Nakamura Yutaka, Yamauchi Kohei, Maemondo Makoto
机构信息
1Division of Pulmonary Medicine, Allergy, and Rheumatology, Department of Internal Medicine, Iwate Medical University School of Medicine, 19-1 Uchimaru, Morioka, 0208505 Japan.
2Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, 1-1-5 Sendagi, Tokyo, 1138603 Japan.
出版信息
Clin Mol Allergy. 2018 Apr 2;16:9. doi: 10.1186/s12948-018-0086-7. eCollection 2018.
BACKGROUND
Single nucleotide polymorphisms (SNPs) in - () are associated with bronchial severity and pulmonary function. CHI3L1 proteins are involved in both innate and adaptive immune responses; however, to date, the correlation of these SNPs and their age of onset of bronchial asthma has not been demonstrated.
METHODS
To address the role of these genetic variations, 390 patients with well-controlled bronchial asthma and living in Japan were recruited, genotyped, and had a pulmonary function test performed on them in this study. To analyze the concentration levels of CHI3L1 protein, bronchial lavage fluids were examined.
RESULTS
Forced expiratory volume in one second, %predicted (%FEV1), was significantly decreased in homozygotes of rs1214194 compared to heterozygotes and wild type. The age of onset of adult bronchial asthma was significantly younger in GG homozygotes of rs4950928 and AA homozygotes of rs1214194 than in the other two genotypes. The concentration of CHI3L1 protein in bronchial lavage fluid increased in both homozygotes of rs4950928 and rs1214194.
CONCLUSIONS
Our study demonstrated that the homozygotes of rs4950928 and rs1214194 of might predict an early onset of bronchial asthma and have the propensity to promote airway remodeling. JMA-IIA00045 remodeling-ICS.
背景
-（）中的单核苷酸多态性（SNP）与支气管严重程度和肺功能相关。几丁质酶3样蛋白1（CHI3L1）参与先天性和适应性免疫反应；然而，迄今为止，这些SNP与支气管哮喘发病年龄之间的相关性尚未得到证实。
方法
为了研究这些基因变异的作用，本研究招募了390名病情得到良好控制且居住在日本的支气管哮喘患者，对其进行基因分型，并进行肺功能测试。为了分析CHI3L1蛋白的浓度水平，对支气管灌洗液进行了检测。
结果
与杂合子和野生型相比，rs1214194纯合子的一秒用力呼气量占预计值百分比（%FEV1）显著降低。rs4950928的GG纯合子和rs1214194的AA纯合子的成人支气管哮喘发病年龄显著低于其他两种基因型。rs4950928和rs1214194的纯合子中支气管灌洗液中CHI3L1蛋白的浓度均升高。
结论
我们的研究表明，rs4950928和rs1214194的纯合子可能预示支气管哮喘的早期发病，并具有促进气道重塑的倾向。JMA-IIA00045重塑-吸入性糖皮质激素。
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