Eimpunth Sasima, Sittinamsuwan Panitta, Pattanaprichakul Penvadee, Silpa-archa Narumol, Sethabutra Piyaroj, Chularojanamontri Leena, Hanamornroongruang Suchanan, Mahaisavariya Punkae
Department of Dermatology, Faculty of Medicine Siriraj Hospital, Bangkok, Thailand.
J Med Assoc Thai. 2012 Mar;95(3):437-43.
Anaplastic large cell lymphoma (ALCL) is one type of lymphoma, which is characterized by the proliferation of pleomorphic large atypical lymphoid cells expressing CD30 antigen. ALCL involving skin can be either primary cutaneous disease or cutaneous involvement secondary from systemic disease. Data of clinical manifestation of cutaneous ALCL in Thai patients is limited. ALCL in Thai patients may differ from other groups of patients.
To study the clinical manifestation of cutaneous ALCL in patients of Faculty of Medicine Siriraj Hospital, Thailand.
Medical records of nine patients with histopathologic diagnosis of ALCL from skin biopsy at Faculty of Medicine Siriraj Hospital were reviewed.
Of nine patients, four patients were diagnosed as primary cutaneous ALCL, four patients as systemic ALCL with secondary skin involvement, and one patient as combined primary cutaneous ALCL and lymphomatoid papulosis. Three primary cutaneous ALCL patients had no recurrence of disease during 6-year follow-up. However all systemic ALCL patients died at one day to 1.5 years after diagnosis.
Clinical manifestation and clinical course of Thai patients with anaplastic large cell lymphoma corresponded with the data from other patient population.
间变性大细胞淋巴瘤（ALCL）是淋巴瘤的一种类型，其特征为表达CD30抗原的多形性大的非典型淋巴样细胞增殖。累及皮肤的ALCL可以是原发性皮肤疾病，也可以是系统性疾病继发的皮肤受累。泰国患者皮肤ALCL的临床表现数据有限。泰国患者的ALCL可能与其他患者群体不同。
研究泰国诗里拉吉医院医学院患者皮肤ALCL的临床表现。
回顾了泰国诗里拉吉医院医学院9例经皮肤活检组织病理学诊断为ALCL患者的病历。
9例患者中，有4例被诊断为原发性皮肤ALCL，4例为系统性ALCL伴继发性皮肤受累，1例为原发性皮肤ALCL合并淋巴瘤样丘疹病。3例原发性皮肤ALCL患者在6年随访期间无疾病复发。然而，所有系统性ALCL患者在诊断后1天至1.5年死亡。
泰国间变性大细胞淋巴瘤患者的临床表现和临床病程与其他患者群体的数据相符。
