El-Toni Ahmed Mohamed, Khan Aslam, Ibrahim Mohamed Abbas, Labis Joselito Puzon, badr Gamal, Al-Hoshan Mansour, Yin Shu, Sato Tsugio
King Abdullah Institute for Nanotechnology, King Saud University, Riyadh 11451, Saudi Arabia.
J Colloid Interface Sci. 2012 Jul 15;378(1):83-92. doi: 10.1016/j.jcis.2012.04.006. Epub 2012 Apr 17.
In this work, we demonstrate a simple two-pot approach to double mesoporous core-shell silica spheres (DMCSSs) with uniform size of 245-790 nm, shell thickness of 41-80 nm and surface area and total pore volume of 141-618 m(2) g(-1) and 0.14-0.585 cc g(-1), respectively. First, solid silica spherical particles were synthesized by the Stöber method and used as a core. Second, a mesoporous shell could be formed around the silica cores by using an anionic surfactant and a co-structure directing agent. It was found that mesopores can be anchored within dense silica cores during mesoporous silica shell formation, synchronously the base group with surfactant assistant can etch the dense silica cores to re-organize new mesostructure, so that double mesoporous core-shell silica sphere (DMCSS) structure can be obtained by a single surfactant-templating step. The spherical size and porosity of the silica cores of DMCSS together with shell thickness can be tuned by controlling Stöber parameters, including the concentrations of ammonia, solvent and tetraethoxysilane and the reaction time. DMCSS were loaded with ketoprofen and thymoquinone, which are an anti-inflammatory and a potential novel anti-cancer drug, respectively. Both drugs showed controlled release behavior from the pores of DMCSS. Drug uptakes within DMCSS were ~27 and 81 wt.% for ketoprofen and thymoquinone, respectively. Furthermore, DMCSS loaded with thymoquinone was more effective in inducing cancer cell apoptosis than uncontained thymoquinone, because of the slow release of the drug from the mesoporous structure.
在本工作中，我们展示了一种简单的两步法来制备双介孔核壳二氧化硅球（DMCSSs），其尺寸均匀，为245 - 790 nm，壳厚度为41 - 80 nm，表面积和总孔体积分别为141 - 618 m² g⁻¹和0.14 - 0.585 cc g⁻¹。首先，通过Stöber法合成固体二氧化硅球形颗粒并用作核。其次，通过使用阴离子表面活性剂和共结构导向剂，可以在二氧化硅核周围形成介孔壳。研究发现，在介孔二氧化硅壳形成过程中，介孔可锚定在致密的二氧化硅核内，同时表面活性剂辅助的碱性基团可蚀刻致密的二氧化硅核以重新组织新的介观结构，从而通过单一的表面活性剂模板步骤获得双介孔核壳二氧化硅球（DMCSS）结构。通过控制Stöber参数，包括氨、溶剂和四乙氧基硅烷的浓度以及反应时间，可以调节DMCSS的二氧化硅核的球形尺寸、孔隙率以及壳厚度。DMCSS分别负载了酮洛芬和百里醌，它们分别是一种抗炎药和一种潜在的新型抗癌药。两种药物均从DMCSS的孔中呈现出控释行为。DMCSS对酮洛芬和百里醌的药物摄取量分别约为27 wt.%和81 wt.%。此外，负载百里醌的DMCSS在诱导癌细胞凋亡方面比未负载的百里醌更有效，这是因为药物从介孔结构中缓慢释放。
