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磁性纳米核上介孔壳层形成的合成参数优化及其作为多西他赛抗癌药物纳米载体的应用。

Optimization of synthesis parameters for mesoporous shell formation on magnetic nanocores and their application as nanocarriers for docetaxel cancer drug.

作者信息

El-Toni Ahmed Mohamed, Ibrahim Mohamed Abbas, Labis Joselito Puzon, Khan Aslam, Alhoshan Mansour

机构信息

King Abdullah Institute for Nanotechnology, King Saud University, Riyadh 11451, Saudi Arabia.

出版信息

Int J Mol Sci. 2013 May 30;14(6):11496-509. doi: 10.3390/ijms140611496.

DOI:10.3390/ijms140611496
PMID:23722659
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3709744/
Abstract

In this work, Fe3O4@SiO2 nanoparticles were coated with mesoporous silica shell by S-N+I- pathway by using anionic surfactant (S-) and co-structure directing agent (N+). The role of co-structure directing agent (CSDA) is to assist the electrostatic interaction between negatively charged silica layers and the negatively charged surfactant molecules. Prior to the mesoporous shell formation step, magnetic cores were coated with a dense silica layer to prevent iron oxide cores from leaching into the mother system under any acidic circumstances. However, it was found that both dense and mesoporous coating parameters affect the textural properties of the produced mesoporous silica shell (i.e., surface area, pore volume and shell thickness). The synthesized Fe3O4@SiO2@m-SiO2 (MCMSS) nanoparticles have been characterized by low-angle X-ray diffraction, transmission electron microscopy (TEM), and N2 adsorption-desorption analysis, and magnetic properties. The synthesized particles had dense and mesoporous silica shells of 8-37 nm and 26-50 nm, respectively. Furthermore, MCMSS possessed surface area of ca. 259-621 m2·g-1, and pore volume of ca. 0.216-0.443 cc·g-1. MCMSS showed docetaxcel cancer drug storage capacity of 25-33 w/w% and possessed control release from their mesochannels which suggest them as proper nanocarriers for docetaxcel molecules.

摘要

在本工作中,通过使用阴离子表面活性剂(S-)和共结构导向剂(N+),采用S-N+I-途径在Fe3O4@SiO2纳米颗粒上包覆介孔二氧化硅壳层。共结构导向剂(CSDA)的作用是辅助带负电荷的二氧化硅层与带负电荷的表面活性剂分子之间的静电相互作用。在形成介孔壳层步骤之前,先用致密的二氧化硅层包覆磁核,以防止氧化铁核在任何酸性条件下浸出到母体系中。然而,发现致密涂层和介孔涂层参数都会影响所制备的介孔二氧化硅壳层的织构性质(即表面积、孔体积和壳层厚度)。通过小角X射线衍射、透射电子显微镜(TEM)、N2吸附-脱附分析以及磁性对合成的Fe3O4@SiO2@m-SiO2(MCMSS)纳米颗粒进行了表征。合成的颗粒分别具有8 - 37 nm和26 - 50 nm的致密和介孔二氧化硅壳层。此外,MCMSS的表面积约为259 - 621 m2·g-1,孔体积约为0.216 - 0.443 cc·g-1。MCMSS显示出多西他赛抗癌药物的储存容量为25 - 33 w/w%,并且其介孔道具有控释性能,这表明它们是多西他赛分子合适的纳米载体。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4a3/3709744/98fc58f24b19/ijms-14-11496f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4a3/3709744/c1097d6b5c8c/ijms-14-11496f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4a3/3709744/6ea219dab8dd/ijms-14-11496f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4a3/3709744/7beccdd359ea/ijms-14-11496f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4a3/3709744/98dfb7efa262/ijms-14-11496f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4a3/3709744/0a29237bbf28/ijms-14-11496f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4a3/3709744/98fc58f24b19/ijms-14-11496f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4a3/3709744/c1097d6b5c8c/ijms-14-11496f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4a3/3709744/6ea219dab8dd/ijms-14-11496f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4a3/3709744/7beccdd359ea/ijms-14-11496f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4a3/3709744/98dfb7efa262/ijms-14-11496f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4a3/3709744/0a29237bbf28/ijms-14-11496f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4a3/3709744/98fc58f24b19/ijms-14-11496f6.jpg

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