Manchester Adult Cystic Fibrosis Centre, University Hospital of South Manchester, Southmoor Road, Manchester, M23 9LT, UK.
J Cyst Fibros. 2012 Sep;11(5):458-60. doi: 10.1016/j.jcf.2012.04.002. Epub 2012 May 1.
Burkholderia cepacia complex (BCC) is a group of 17 closely related bacterial species that can cause pulmonary infection in patients with cystic fibrosis (CF). The clinical manifestations of BCC infection are varied but can include cepacia syndrome, which is a rapidly progressing necrotising pneumonia with an almost universally fatal outcome. We report the case of a 38 year old man, known to have chronic infection with the ET12 strain of Burkholderia cenocepacia who developed cepacia syndrome 26 years after initial infection. Aggressive treatment with a combination of 4 intravenous antibiotics, oral corticosteroids and cyclosporin brought about clinical, radiological and biochemical resolution of his cepacia syndrome. This case highlights the possible role of cyclosporin in the treatment of cepacia syndrome.
洋葱伯克霍尔德菌复合体（BCC）是一组 17 种密切相关的细菌，可引起囊性纤维化（CF）患者肺部感染。BCC 感染的临床表现多种多样，但可包括洋葱伯克霍尔德菌综合征，这是一种快速进展的坏死性肺炎，几乎普遍导致死亡。我们报告了一例 38 岁男性，已知患有慢性感染 ET12 型洋葱伯克霍尔德菌，在初次感染后 26 年发生洋葱伯克霍尔德菌综合征。使用 4 种静脉内抗生素、口服皮质类固醇和环孢素联合积极治疗，使他的洋葱伯克霍尔德菌综合征在临床、影像学和生化方面得到缓解。本病例提示环孢素在治疗洋葱伯克霍尔德菌综合征中的可能作用。
