Sousa Sílvia A, Seixas António M M, Marques Joana M M, Leitão Jorge H
Department of Bioengineering, IBB-Institute for Bioengineering and Biosciences, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal.
Associate Laboratory, i4HB-Institute for Health and Bioeconomy at Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal.
Vaccines (Basel). 2021 Jun 18;9(6):670. doi: 10.3390/vaccines9060670.
Human infections caused by the opportunist pathogens complex and are of particular concern due to their severity, their multiple antibiotic resistance, and the limited eradication efficiency of the current available treatments. New therapeutic options have been pursued, being vaccination strategies to prevent or limit these infections as a rational approach to tackle these infections. In this review, immunization and immunotherapy approaches currently available and under study against these bacterial pathogens is reviewed. Ongoing active and passive immunization clinical trials against . infections is also reviewed. Novel identified bacterial targets and their possible exploitation for the development of immunization and immunotherapy strategies against . and . complex and infections are also presented and discussed.
由机会性病原体复合体引起的人类感染因其严重性、多重抗生素耐药性以及当前可用治疗方法有限的根除效率而备受关注。人们一直在探索新的治疗选择，其中疫苗接种策略作为预防或限制这些感染的合理方法来应对这些感染。在本综述中，对目前可用的以及正在研究的针对这些细菌病原体的免疫和免疫治疗方法进行了综述。还综述了针对……感染正在进行的主动和被动免疫临床试验。还介绍并讨论了新发现的细菌靶点及其在开发针对……和……复合体及感染的免疫和免疫治疗策略方面的可能应用。
