Department of Urology, University of Texas Health Science Center at San Antonio (UTHSCSA), San Antonio, TX 78229, USA; Department of Epidemiology, Biostatistics, UTHSCSA, San Antonio, TX 78229, USA; School of Public Health, University of Texas Health Science Center at Houston, Houston, TX 77025, USA; Cancer Therapy and Research Center, UTHSCSA, San Antonio, TX 78229, USA.
Urol Oncol. 2013 Nov;31(8):1464-9. doi: 10.1016/j.urolonc.2012.03.012. Epub 2012 May 1.
Risks of prostate cancer (CaP) and high-grade CaP were evaluated using the Prostate Cancer Prevention Trial Risk Calculator (PCPTRC) in an age-stratified random sample of 1,021 Caucasian and African-American men with no previous diagnosis of CaP, aged 55-74 years, residing in King County, WA, USA.
Median PCPTRC risks of CaP (high-grade CaP) were 15.6% (1.2%), 18.7% (2.0%), 18.5% (2.2%), and 26.4% (5.1%) for 55-59, 60-64, 65-69, and 70-74-year-old men, respectively; 25.2% of men aged 55-59 had a 25% or greater PCPTRC risk of CaP; this increased to 53.1% in men aged 70-74; 9.4% of men aged 55-59 had a 6% or greater PCPTRC risk of high-grade CaP, increasing to 44.1% in men aged 70-74.
PCPTRC risk of CaP in a community of US males is high and confounded with overdetected cancers. In contrast, average community PCPTRC risk of high-grade disease is low and increases gradually by age and may better serve for counseling purposes.
在一项年龄分层的随机抽样研究中，我们对 1021 名未被诊断患有前列腺癌、年龄在 55-74 岁之间、居住在美国华盛顿州金县的白种人和非裔美国男性进行了前列腺癌预防试验风险计算器（PCPTRC）评估，以评估前列腺癌（高级别前列腺癌）的风险。
55-59 岁、60-64 岁、65-69 岁和 70-74 岁男性的中位 PCPTRC 前列腺癌（高级别前列腺癌）风险分别为 15.6%（1.2%）、18.7%（2.0%）、18.5%（2.2%）和 26.4%（5.1%）；55-59 岁男性中有 25.2%的人 PCPTRC 前列腺癌风险为 25%或更高；这一比例在 70-74 岁男性中上升到 53.1%；55-59 岁男性中有 9.4%的人 PCPTRC 高级别前列腺癌风险为 6%或更高，在 70-74 岁男性中上升到 44.1%。
美国男性社区中 PCPTRC 前列腺癌风险较高，并与过度检测的癌症有关。相比之下，普通社区 PCPTRC 高级别疾病的平均风险较低，并且随着年龄的增长逐渐增加，可能更适合用于咨询目的。
