让非裔美国男性作为公民科学家参与验证前列腺癌生物标志物：正在进行的工作。
Engaging African American Men as Citizen Scientists to Validate a Prostate Cancer Biomarker: Work-in-Progress.
作者信息
Watson Karriem S, Henderson Vida, Murray Marcus, Murphy Adam B, Levi Josef Ben, McDowell Tiffany, Holloway-Beth Alfreda, Gogana Pooja, Dixon Michael A, Moore LeAndre, Hall Ivanhoe, Kimbrough Alexander, Molina Yamilé, Winn Robert A
出版信息
Prog Community Health Partnersh. 2019;13(5):103-112. doi: 10.1353/cpr.2019.0043.
BACKGROUND
African American men (AAM) are under-represented in prostate cancer (PCa) research despite known disparities. Screening with prostate-specific antigen (PSA) has low specificity for high-grade PCa leading to PCa over diagnosis. The Prostate Health Index (PHI) has higher specificity for lethal PCa but needs validation in AAM. Engaging AAM as citizen scientists (CSs) may improve participation of AAM in PCa research.Results and Lessons Learned: Eight CSs completed all training modules and 139 AAM were recruited. Challenges included equity in research leadership among multiple principal investigators (PIs) and coordinating CSs trainings.
CONCLUSIONS
Engaging AAM CSs can support engaging/recruiting AAM in PCa biomarker validation research. Equity among multiple stakeholders can be challenging, but proves beneficial in engaging AAM in research.
OBJECTIVES
Assess feasibility of mobilizing CSs to recruit AAM as controls for PHI PCa validation biomarker study.
METHODS
We highlight social networks/assets of stakeholders, CSs curriculum development/implementation, and recruitment of healthy controls for PHI validation.
背景
尽管已知存在差异，但非裔美国男性（AAM）在前列腺癌（PCa）研究中的代表性不足。使用前列腺特异性抗原（PSA）进行筛查对高级别PCa的特异性较低，导致PCa过度诊断。前列腺健康指数（PHI）对致命性PCa具有更高的特异性，但需要在AAM中进行验证。让AAM作为公民科学家（CSs）参与可能会提高AAM在PCa研究中的参与度。
结果与经验教训
8名CSs完成了所有培训模块，并招募了139名AAM。挑战包括多个主要研究者（PIs）之间在研究领导权方面的公平性以及协调CSs培训。
结论
让AAM CSs参与可以支持在PCa生物标志物验证研究中吸引/招募AAM。多个利益相关者之间的公平性可能具有挑战性，但事实证明这对让AAM参与研究是有益的。
目标
评估动员CSs招募AAM作为PHI PCa验证生物标志物研究对照的可行性。
方法
我们重点介绍了利益相关者的社交网络/资产、CSs课程开发/实施以及为PHI验证招募健康对照的情况。
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