2型单纯疱疹病毒DNA对培养的叙利亚仓鼠胚胎细胞的致瘤转化作用
Neoplastic transformation of cultured Syrian hamster embryo cells by DNA of herpes simplex virus type 2.
作者信息
Jariwalla R J, Aurelian L, Ts'o P O
出版信息
J Virol. 1979 Apr;30(1):404-9. doi: 10.1128/JVI.30.1.404-409.1979.
Abstract
Syrian hamster embryo cells were transformed to a neoplastic phenotype after exposure to herpes simplex virus type 2 (S-1) DNA at concentrations (less than or equal to 0.01 microgram per 60-mm dish) at which infectivity was no longer demonstrable. Transformed cells manifested in vitro phenotypic properties characteristic of the neoplastic state, expressed herpes simplex virus-specific antigens, and induced invasive tumors in vivo. Transfection and transformation of Syrian hamster embryo cells with herpes simplex virus type 2 DNA or its fragments is a suitable system for investigating the structure and function of herpes simplex virus-transforming gene(s).
摘要
叙利亚仓鼠胚胎细胞在暴露于2型单纯疱疹病毒（S-1）DNA后，被转化为肿瘤表型，此时DNA浓度（小于或等于每60毫米培养皿0.01微克）已无法检测到感染性。转化后的细胞表现出肿瘤状态特有的体外表型特征，表达单纯疱疹病毒特异性抗原，并在体内诱发侵袭性肿瘤。用2型单纯疱疹病毒DNA或其片段转染和转化叙利亚仓鼠胚胎细胞，是研究单纯疱疹病毒转化基因结构和功能的合适系统。
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