Myeloid-derived suppressor cells in sepsis: friend or foe?
作者信息
Cuenca Alex G, Moldawer Lyle L
出版信息
Intensive Care Med. 2012 Jun;38(6):928-30. doi: 10.1007/s00134-012-2575-3. Epub 2012 May 3.
Abstract
摘要
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Myeloid-derived suppressor cells in sepsis: friend or foe?脓毒症中的髓源性抑制细胞：朋友还是敌人？
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本文引用的文献
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Immunosuppression in patients who die of sepsis and multiple organ failure.死于脓毒症和多器官衰竭的患者的免疫抑制。
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Sepsis induces early alterations in innate immunity that impact mortality to secondary infection.败血症会导致先天免疫的早期改变，从而影响继发感染的死亡率。
J Immunol. 2011 Jan 1;186(1):195-202. doi: 10.4049/jimmunol.1002104. Epub 2010 Nov 24.
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A paradoxical role for myeloid-derived suppressor cells in sepsis and trauma.髓系来源的抑制性细胞在脓毒症和创伤中的矛盾作用。
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Immunotherapy for sepsis--a new approach against an ancient foe.脓毒症的免疫疗法——对抗古老敌人的新方法。
N Engl J Med. 2010 Jul 1;363(1):87-9. doi: 10.1056/NEJMcibr1004371.
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Hepatic acute-phase proteins control innate immune responses during infection by promoting myeloid-derived suppressor cell function.肝急性期蛋白通过促进髓源性抑制细胞功能来控制感染期间的固有免疫反应。
J Exp Med. 2010 Jul 5;207(7):1453-64. doi: 10.1084/jem.20091474. Epub 2010 Jun 7.
6
Myeloid-derived suppressor cells as regulators of the immune system.髓源性抑制细胞作为免疫系统的调节因子。
Nat Rev Immunol. 2009 Mar;9(3):162-74. doi: 10.1038/nri2506.
7
Increased circulating regulatory T cells (CD4(+)CD25 (+)CD127 (-)) contribute to lymphocyte anergy in septic shock patients.循环调节性T细胞（CD4(+)CD25(+)CD127(-)）数量增加促使脓毒性休克患者出现淋巴细胞无反应性。
Intensive Care Med. 2009 Apr;35(4):678-86. doi: 10.1007/s00134-008-1337-8. Epub 2008 Oct 23.
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Regulatory T cell populations in sepsis and trauma.脓毒症和创伤中的调节性T细胞群体
J Leukoc Biol. 2008 Mar;83(3):523-35. doi: 10.1189/jlb.0607371. Epub 2007 Oct 3.
9
MyD88-dependent expansion of an immature GR-1(+)CD11b(+) population induces T cell suppression and Th2 polarization in sepsis.髓样分化因子88（MyD88）依赖的未成熟GR-1(+)CD11b(+)细胞群扩增在脓毒症中诱导T细胞抑制和Th2极化。
J Exp Med. 2007 Jun 11;204(6):1463-74. doi: 10.1084/jem.20062602. Epub 2007 Jun 4.
10
An intervention to decrease catheter-related bloodstream infections in the ICU.一项降低重症监护病房导管相关血流感染的干预措施。
N Engl J Med. 2006 Dec 28;355(26):2725-32. doi: 10.1056/NEJMoa061115.
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