Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada.
The Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Unity Health Toronto, 209 Victoria Street, Toronto, ON, M5B1T8, Canada.
Mol Med. 2022 Aug 19;28(1):99. doi: 10.1186/s10020-022-00527-z.
Sepsis is defined as a state of multisystem organ dysfunction secondary to a dysregulated host response to infection and causes millions of deaths worldwide annually. Novel ways to counteract this disease are needed and such tools may be heralded by a detailed understanding of its molecular pathogenesis. MiRNAs are small RNA molecules that target mRNAs to inhibit or degrade their translation and have important roles in several disease processes including sepsis.
The current review adopted a strategic approach to analyzing the widespread literature on the topic of miRNAs and sepsis. A pubmed search of "miRNA or microRNA or small RNA and sepsis not review" up to and including January 2021 led to 1140 manuscripts which were reviewed. Two hundred and thirty-three relevant papers were scrutinized for their content and important themes on the topic were identified and subsequently discussed, including an in-depth look at deregulated miRNAs in sepsis in peripheral blood, myeloid derived suppressor cells and extracellular vesicles.
Our analysis yielded important observations. Certain miRNAs, namely miR-150 and miR-146a, have consistent directional changes in peripheral blood of septic patients across numerous studies with strong data supporting a role in sepsis pathogenesis. Furthermore, a large body of literature show miRNA signatures of clinical relevance, and lastly, many miRNAs deregulated in sepsis are associated with the process of endothelial dysfunction. This review offers a widespread, up-to-date and detailed discussion of the role of miRNAs in sepsis and is meant to stimulate further work in the field due to the potential of these small miRNAs in prompt diagnostics, prognostication and therapeutic agency.
败血症是一种由宿主对感染的失调反应引起的多系统器官功能障碍状态，每年在全球导致数百万人死亡。需要寻找新的方法来对抗这种疾病，而这种工具可能预示着对其分子发病机制的详细了解。miRNA 是一种靶向 mRNA 以抑制或降解其翻译的小 RNA 分子，在包括败血症在内的几种疾病过程中具有重要作用。
本综述采用策略性方法分析了 miRNA 和败血症相关的广泛文献。在 2021 年 1 月之前，对“miRNA 或 microRNA 或 small RNA 和 sepsis not review”进行 pubmed 搜索，共得到 1140 篇手稿，对其进行了审查。对 233 篇相关论文进行了内容审查，并确定了该主题的重要主题，并随后进行了讨论，包括深入研究败血症患者外周血、髓源性抑制细胞和细胞外囊泡中失调的 miRNA。
我们的分析得出了重要的观察结果。某些 miRNA，即 miR-150 和 miR-146a，在许多研究中，在败血症患者的外周血中具有一致的定向变化，具有很强的数据支持其在败血症发病机制中的作用。此外，大量文献显示 miRNA 具有临床相关性特征，最后，败血症中失调的许多 miRNA 与内皮功能障碍过程有关。本综述广泛、最新和详细地讨论了 miRNA 在败血症中的作用，并由于这些小 miRNA 在即时诊断、预后和治疗中的潜力，旨在激发该领域的进一步工作。
