Clinic of Neurology, University of Defence, Faculty of Medicine of the Military Medical Academy, Crnotravska 17, 11 000, Belgrade, Serbia,
Neurol Sci. 2012 Dec;33(6):1369-74. doi: 10.1007/s10072-012-1099-5. Epub 2012 May 3.
Cognitive impairment is present in up to 65 % of multiple sclerosis (MS) patients. The Brief Repeatable Battery of neuropsychological tests (BRB) is one of the most used neuropsychological tools for cognitive assessment in MS. However, relative lack of normative data limits its application in research and clinical practice. In order to obtain normative data for a Serbian population, we administered the BRB version A to 140 healthy subjects and assessed the influence of demographic factors such as gender, age, and education on the tests' scores. We also calculated corrections for these factors. Higher education was associated with better performance on all the tests. Age influenced all the tests, except the word list generation, higher age being associated with worse performance on all other tests. Women performed worse on the paced auditory serial addition test 2, no other gender differences were observed. Our data obtained for the Serbian population could further improve use of the BRB in clinical practice and for the research purposes, establishing cognitive evaluation as a part of standard neurological examination of MS patients.
认知障碍存在于多达 65%的多发性硬化症（MS）患者中。简短重复认知测试（BRB）是用于 MS 认知评估的最常用的神经心理学工具之一。然而，相对缺乏规范数据限制了其在研究和临床实践中的应用。为了获得塞尔维亚人群的规范数据，我们对 140 名健康受试者进行了 BRB 版本 A 的测试，并评估了性别、年龄和教育等人口统计学因素对测试成绩的影响。我们还针对这些因素进行了修正。较高的教育程度与所有测试的表现更好相关。年龄影响了所有的测试，除了单词列表生成测试，年龄较高与所有其他测试的表现更差相关。女性在连续听觉加法测试 2 中表现较差，未观察到其他性别差异。我们在塞尔维亚人群中获得的数据可以进一步改善 BRB 在临床实践和研究中的使用，将认知评估作为 MS 患者标准神经检查的一部分。
