Drug Delivery and Novel Targeting Research Group, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur, 50300, Malaysia.
Arch Pharm Res. 2012 Mar;35(4):579-93. doi: 10.1007/s12272-012-0401-7. Epub 2012 May 3.
Synthetic membranes are composed of thin sheets of polymeric macromolecules that can control the passage of components through them. Generally, synthetic membranes used in drug diffusion studies have one of two functions: skin simulation or quality control. Synthetic membranes for skin simulation, such as the silicone-based membranes polydimethylsiloxane and Carbosil, are generally hydrophobic and rate limiting, imitating the stratum corneum. In contrast, synthetic membranes for quality control, such as cellulose esters and polysulfone, are required to act as a support rather than a barrier. These synthetic membranes also often contain pores; hence, they are called porous membranes. The significance of Franz diffusion studies and synthetic membranes in quality control studies involves an understanding of the fundamentals of synthetic membranes. This article provides a general overview of synthetic membranes, including a brief background of the history and the common applications of synthetic membranes. This review then explores the types of synthetic membranes, the transport mechanisms across them, and their relevance in choosing a synthetic membrane in Franz diffusion cell studies for formulation assessment purposes.
合成膜由薄的聚合物大分子薄片组成，可控制组件通过它们的传递。通常，用于药物扩散研究的合成膜具有以下两种功能之一：皮肤模拟或质量控制。用于皮肤模拟的合成膜，如基于硅的聚二甲基硅氧烷和 Carbosil，通常是疏水性的且具有限制作用，模拟角质层。相比之下，用于质量控制的合成膜，如纤维素酯和聚砜，需要作为支撑而不是屏障。这些合成膜还经常含有孔，因此被称为多孔膜。Franz 扩散研究和质量控制研究中合成膜的意义涉及对合成膜基本原理的理解。本文概述了合成膜，包括合成膜的历史和常见应用的简要背景。然后，本综述探讨了合成膜的类型、它们的跨膜传输机制以及在 Franz 扩散池研究中选择合成膜用于制剂评估目的时的相关性。
