患有蹒跚病的猫中博尔纳病病毒感染的标志物。
Markers of Borna disease virus infection in cats with staggering disease.
作者信息
Wensman Jonas J, Jäderlund Karin H, Gustavsson Malin H, Hansson-Hamlin Helene, Karlstam Erika, Lilliehöök Inger, Oström Inga-Lena Ö, Belák Sándor, Berg Mikael, Holst Bodil S
机构信息
Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, Uppsala, Sweden.
出版信息
J Feline Med Surg. 2012 Aug;14(8):573-82. doi: 10.1177/1098612X12446638. Epub 2012 May 2.
Borna disease virus (BDV) is a RNA-virus causing neurological disorders in a wide range of mammals. In cats, BDV infection may cause staggering disease. Presently, staggering disease is a tentative clinical diagnosis, only confirmed at necropsy. In this study, cats with staggering disease were investigated to study markers of BDV infection aiming for improvement of current diagnostics. Nineteen cats fulfilled the inclusion criteria based on neurological signs and pathological findings. In 17/19 cats, BDV infection markers (BDV-specific antibodies and/or BDV-RNA) were found, and antibodies in serum (13/16, 81%) were the most common marker. BDV-RNA was found in 11/19 cats (58%). In a reference population without neurological signs, 4/25 cats were seropositive (16%). The clinical history and neurological signs in combination with presence of BDV infection markers, where serology and rRT-PCR on blood can be helpful tools, improve the diagnostic accuracy in the living cat.
博尔纳病病毒（BDV）是一种RNA病毒，可在多种哺乳动物中引发神经紊乱。在猫身上，BDV感染可能导致蹒跚病。目前，蹒跚病是一种初步的临床诊断，只有在尸检时才能确诊。在本研究中，对患有蹒跚病的猫进行了调查，以研究BDV感染的标志物，旨在改进当前的诊断方法。19只猫根据神经症状和病理结果符合纳入标准。在19只猫中的17只中，发现了BDV感染标志物（BDV特异性抗体和/或BDV-RNA），血清中的抗体（16只中的13只，81%）是最常见的标志物。在19只猫中的11只（58%）中发现了BDV-RNA。在没有神经症状的对照群体中，25只猫中有4只血清呈阳性（16%）。临床病史和神经症状，再加上BDV感染标志物的存在，其中血液血清学和逆转录实时聚合酶链反应（rRT-PCR）可能是有用的工具，提高了对活体猫的诊断准确性。
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